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Checkpoint Inhibitor-Induced Pneumonitis: Incidence and Management
Purpose of ReviewDespite immune checkpoint inhibitors’ (ICIs) many notable benefits, they carry the risk of immune-related adverse events (irAEs)....
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Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis
As immune checkpoint inhibitors (ICIs) are widely used, a series of immune-related adverse events (irAEs) have been reported, including immune...
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Deciphering pathogenic cellular module at single-cell resolution in checkpoint inhibitor-related pneumonitis
Checkpoint inhibitor pneumonitis (CIP) is the most common fatal immune-related adverse event; however, its pathophysiology remains largely unknown....
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A Risk-Scoring Model for Severe Checkpoint Inhibitor-Related Pneumonitis: A Case–Control Study
Background and ObjectiveCheckpoint inhibitor-related pneumonitis (CIP) is one of the most common serious and fatal adverse events associated with...
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Risk factors of immune checkpoint inhibitor-related pneumonitis after neoadjuvant immunochemotherapy for resectable NSCLC
BackgroundThe incidence of checkpoint inhibitor-associated pneumonitis (CIP) in advanced non-small cell lung cancer (NSCLC) has been substantiated...
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Treatment patterns and outcomes of high-grade immune checkpoint inhibitor-related pneumonitis in an oncology hospitalist service
PurposeImmune checkpoint inhibitors (ICI) have become standard of care for some types of lung cancer. Along with expanding usage comes the emergence...
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Association between pre-treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis
BackgroundImmune checkpoint inhibitors (ICIs) are a first-line treatment for various metastatic solid tumors. Pneumonitis is a potentially...
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Immune checkpoint inhibitor-related pneumonitis and COVID-19: a case-matched comparison of CT findings
ObjectivesTo compare the radiological findings of immune checkpoint inhibitor-related pneumonitis (IRP) and COVID-19 pneumonia, evaluating the...
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Radiation and immune checkpoint inhibitor-mediated pneumonitis risk stratification in patients with locally advanced non-small cell lung cancer: role of functional lung radiomics?
BackgroundPatients undergoing chemoradiation and immune checkpoint inhibitor (ICI) therapy for locally advanced non-small cell lung cancer (NSCLC)...
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Checkpoint inhibitor pneumonitis: Short review of literature and case report
Immune checkpoint blockade (ICB) has fundamentally improved the treatment landscape of advanced lung cancer. Improved tolerability and encouraging...
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Radiation recall pneumonitis triggered by an immune checkpoint inhibitor following re-irradiation in a lung cancer patient: a case report
BackgroundRadiation recall pneumonitis (RRP) is unpredictable but associated with severe radiation damage in previously irradiated fields....
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Risk of pneumonitis in non-small cell lung cancer patients with preexisting interstitial lung diseases treated with immune checkpoint inhibitors: a nationwide retrospective cohort study
BackgroundChemotherapy for non-small cell lung cancer (NSCLC) patients with preexisting interstitial lung diseases (ILDs) increases the risk of...
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Clinical outcomes and risk factor of immune checkpoint inhibitors-related pneumonitis in non-small cell lung cancer patients with chronic obstructive pulmonary disease
Objectives:Chronic obstructive pulmonary disease (COPD) is the most common co-morbidity associated with non-small cell lung cancer (NSCLC) patients....
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Clinical implications of bronchoscopy for immune checkpoint inhibitor-related pneumonitis in patients with non-small cell lung cancer
BackgroundThe utility of bronchoscopy for patients with suspected immune checkpoint inhibitor (ICI)-related pneumonitis is currently debatable. The...
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Integrative Oncology Approaches to Supporting Immune Checkpoint Inhibitor Treatment of Solid Tumours
Purpose of ReviewThe goal of this review was to examine the role and practical applications of integrative oncology strategies in supporting immune...
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Immune checkpoint inhibitor-associated adrenal insufficiency in Chinese cancer patients: a retrospective analysis
PurposeImmune checkpoint inhibitors (ICIs) are of great success in cancer therapy. This study aimed to identify adrenal insufficiency (AI) associated...
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Establishment and validation of nomogram for predicting immuno checkpoint inhibitor related pneumonia
ObjectiveCancer is one of the main causes of death worldwide. Although immunotherapy brings hope for cancer treatment, it is also accompanied by...
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Analysis of cytokines in serum and bronchoalveolar lavage fluid in patients with immune-checkpoint inhibitor-associated pneumonitis: a cross-sectional case–control study
PurposeImmune-checkpoint inhibitors (ICI) present a new treatment for malignancies by boosting the immune system. This has led to a variety of...
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Immune checkpoint inhibitor associated epidermal necrosis, beyond SJS and TEN: a review of 98 cases
Immune checkpoint inhibitor (ICI) therapies carry the risk of major immune-related adverse events (irAEs). Among the most severe irAEs is epidermal...