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Metabolomic profiles of ovariectomized mice and their associations with body composition and frailty-related parameters in postmenopausal women
BackgroundMenopause, a dramatical estrogen-deficient condition, is considered the most significant milestone in women’s health.
Purpose ...
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Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort
BackgroundMetabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study...
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A systematic review of patient-reported outcome measures for advanced skin cancer patients
Many patient-reported outcome measures (PROMs) have been used to study quality of life (QOL) in the skin cancer population. Advanced melanoma and...
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Plasma metabolomic profiles for colorectal cancer precursors in women
How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested...
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Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression
Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are...
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Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes
Aims/hypothesisEmerging evidence suggests that in addition to hyperglycaemia, dyslipidaemia could represent a contributing pathogenetic factor to...
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Differences in metabolomic profiles between Black and White women in the U.S.: Analyses from two prospective cohorts
There is growing interest in incorporating metabolomics into public health practice. However, Black women are under-represented in many metabolomics...
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Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts
BackgroundMetabolic Syndrome (MetS) is characterized by risk factors such as abdominal obesity, hypertriglyceridemia, low high-density lipoprotein...
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The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes
Aims/hypothesisDiets with higher inflammatory and insulinaemic potential have been associated with an increased risk of type 2 diabetes. However, it...
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Prospective analysis of circulating metabolites and breast cancer in EPIC
BackgroundMetabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we...
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Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
BackgroundEpidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately....
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A 6-month exercise intervention clinical trial in women: effects of physical activity on multi-omics biomarkers and health during the first wave of COVID-19 in Korea
BackgroundCoronavirus disease 2019 (COVID-19) was first reported in December 2019 and the first case in Korea was confirmed on January 20, 2020. Due...
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Exploring the metabolomics profile of frailty- a systematic review
BackgroundFrailty is a multifaceted geriatric syndrome characterized by an increased vulnerability to stressful events. metabolomics studies are...
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Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia
BackgroundSarcopenia is defined as the disease of muscle loss and dysfunction. The prevalence of sarcopenia is strongly age-dependent. It could bring...
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Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
BackgroundThe mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of...
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Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia
BackgroundSleep disturbances are a common occurrence in patients with schizophrenia, yet the underlying pathogenesis remain poorly understood. Here,...
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Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration
Subanesthetic-dose racemic ( R,S )-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD)...
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Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes
BackgroundA healthy lifestyle (HL) has been inversely related to type 2 diabetes (T2D) and cardiovascular disease (CVD). However, few studies have...
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Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy
BackgroundDilation may be the first right ventricular change and accelerates the progression of threatening ventricular tachyarrhythmias and heart...
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Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease
BackgroundLegume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential...
