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Allostasis and the origins of adult-onset diabetes
Physiological plasticity enables homeostasis to be maintained in biological systems, but when such allostasis fails, then disease can develop. In a...
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Protracted abstinence in males with an opioid use disorder: partial recovery of nucleus accumbens function
Opioid use disorder (OUD) affects more than 27 million people globally accounting for more than 300,000 deaths annually. Protracted abstinence among...
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The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications
Mitochondrial metabolism can contribute to nuclear histone acetylation among other epigenetic mechanisms. A central aspect of this signaling pathway...
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Religious Involvement and Allostatic Resilience: Findings from a Community Study of Black and White Americans
Wide inequities in stress and health have been documented between Black and White women and men in the United States. This study asks: How does...
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Post-COVID dysautonomias: what we know and (mainly) what we don’t know
Following on from the COVID-19 pandemic is another worldwide public health challenge that is referred to variously as long COVID, post-COVID syndrome...
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The extended autonomic system, dyshomeostasis, and COVID-19
The pandemic viral illness COVID-19 is especially life-threatening in the elderly and in those with any of a variety of chronic medical conditions....
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Associations between allostatic load and hepatic steatosis and liver fibrosis: evidence from NHANES 2017–2020
BackgroundAllostatic load, the cumulative strain resulting from chronic stress responses, has been linked to disease occurrence and progression, yet...
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Allostatic Load and Breast Cancer: a Systematic Review of the Literature
Purpose of the ReviewThis systematic literature review aims to synthesize the existing literature on allostatic load and breast cancer.
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Intergenerational Transmission of Trauma
When individuals experience traumatic events, the impact can extend beyond their own lifetimes and affect their descendants in long-lasting and...
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Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity
Purpose of Review“Healthy aging” is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness....
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Unpredictable chronic mild stress shows neuronal remodeling in multipolar projection neurons of hippocampal complex in postnatal chicks
The hippocampal complex of birds is a narrow-curved strip of tissue that plays a crucial role in learning, memory, spatial navigation, and emotional...
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Migraine chronification as an allostatic disorder: a proof-of-concept study
ObjectiveThe underpinning biologics of migraine chronification are not well understood. We aim to investigate the role of the cumulative burden of...
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The Role of Racism in Childhood Obesity
Purpose of ReviewObesity rates continue to rise among children and have shown persistent racial disparities. Racism plays a potentially essential and...
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Cue-Centered Therapy for Youth Experiencing Posttraumatic Symptoms
PurposeFew of the existing evidence-based interventions for child trauma exposure were specifically designed to address experiences and outcomes of...
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Stress Biomarkers Transferred Into the Female Reproductive Tract by Seminal Plasma Are Associated with ICSI Outcomes
This study aimed to determine whether male stress is related to seminal stress biomarkers and pregnancy achievement in women exposed to their...
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Resilience as a predictor of habituation
Habituation refers to the physiological adaptation to recurrent stressors, which can be measured by cortisol levels, and is considered a central...
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Endocrine responses of the stress system to different types of exercise
Physical activity is an important part of human lifestyle although a large percentage of the population remains sedentary. Exercise represents a...
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The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children
PurposeThe hormonal thyroid changes related to obesity, even when in the euthyroid state, may contribute to the unfavorable cardio-metabolic profile...
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Out of control: computational dynamic control dysfunction in stress- and anxiety-related disorders
Control theory, which has played a central role in technological progress over the last 150 years, has also yielded critical insights into biology...
