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Avanafil as a Novel Therapeutic Agent Against LPS-Induced Acute Lung Injury via Increasing CGMP to Downregulate the TLR4-NF-κB-NLRP3 Inflammasome Signaling Pathway
AimWe demonstrate the effect of PDE5 inhibitors in cases of acute lung injury via the relationship between cGMP/NO and the TLR4-NF-κB-NLRP3 pathway.
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Osteocytes and Primary Cilia
Purpose of ReviewThe purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in...
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Carbohydrate ingestion does not suppress increases in fatty acid-binding protein 4 concentrations post-acute aerobic exercise in healthy men: a randomized crossover study
BackgroundFatty acid-binding protein 4 (FABP4) has been associated with cardiovascular disease and diabetes. Acute aerobic exercise increases...
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Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction
BackgroundThe activation of G protein-coupled receptors (GPCR) signaling by external stimuli has been implicated in inducing cardiac stress and...
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Cognitive deficits in primary hyperparathyroidism – what we know and what we do not know: A narrative review
Classic symptoms of primary hyperparathyroidism (PHPT) are seen in approximately 20% of patients. While features such as kidney stones and skeletal...
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Hypocalcemia in the Immediate Postoperative Period Following Metabolic Bariatric Surgery – Hype or Harm?
PurposeHypocalcemia post-metabolic bariatric surgery (MBS) is a known long-term complication after hypoabsorptive procedures. However, data on...
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Association of OPRM1 with addiction: a review on drug, alcohol and smoking addiction in worldwide population
BackgroundDrugs are chemicals which can disrupt the nerve cell functions of the brain. The present study aims to investigate the addiction related...
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Comparison of allergy prevalence using brinzolamide 1.0% / brimonidine 0.2% fixed combination with and without β-blocker in glaucoma patients: a retrospective cohort study
BackgroundGlaucoma treatment often involves multi-drug regimens, which can lead to poor adherence and side effects. Fixed-dose combinations aim to...
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Histamine receptors in heart failure
The biogenic amine, histamine, is found predominantly in mast cells, as well as specific histaminergic neurons. Histamine exerts its many and varied...
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Evaluating the effectiveness of melatonin in reducing the risk of foot ulcers in diabetic patients
ObjectivesDiabetes and its complications, as a major health concern, are associated with morbidity and mortality around the world. One of these...
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Evaluation of platelet-rich fibrin matrix combined with PGE-1 injection on erectile function in patients with refractory response to PDE5-I: a randomized placebo-controlled study
PurposeWe studied the effect of a platelet-rich fibrin matrix (PRFM) combined with prostaglandin E-1 (PGE-1) injection on erectile function in...
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Altered arginine vasopressin-cyclic AMP-aquaporin 2 pathway in patients with chronic kidney disease
BackgroundIn the collecting ducts of the kidney, arginine vasopressin (AVP), cyclic adenosine monophosphate (cAMP), and aquaporin 2 (AQP2) play a...
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Correlation of parasite density and biochemical parameters in children with malaria infection in Calabar, South-South Nigeria
BackgroundMalaria parasitemia is associated with premature, excessive hemolysis, induction of oxidative stress, and derangement in metabolism of...
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Effect of Sperm 26S Proteasome on Embryo Formation and Development in In Vitro Fertilization
The aim of this study was to evaluate the effects of sperm proteasome activity on fertilization outcome and embryo development after IVF. Following...
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The vascular phenotype of BPD: new basic science insights—new precision medicine approaches
AbstractBronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Up to 1/3 of children with BPD develop pulmonary...
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Characterization of sporadic somatotropinomas with high GIP receptor expression
PurposeTo analyze the expression of glucose-dependent insulinotropic polypeptide receptor ( GIPR) in somatotropinomas specimens and compare clinical,...
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Anti-inflammatory effects of the prostaglandin D2/prostaglandin DP1 receptor and lipocalin-type prostaglandin D2 synthase/prostaglandin D2 pathways in bacteria-induced bovine endometrial tissue
Dairy cows often develop different degrees of endometritis after calving and this is attributed to pathogenic bacterial infections such as by Escherich...
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Multimodal Migraine Management and the Pursuit of Migraine Freedom: A Narrative Review
Migraine is a neurologic disease with a complex pathophysiology that can be controlled with current treatment options but not cured. Therefore,...
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Increasing serum alkaline phosphatase is associated with bone deformity progression for patients with polyostotic fibrous dysplasia
BackgroundFibrous dysplasia (FD) is a rare bone disorder in which normal intramedullary bone is replaced by fibro-osseous tissue, which is...
