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Evaluation of platelet-rich fibrin matrix combined with PGE-1 injection on erectile function in patients with refractory response to PDE5-I: a randomized placebo-controlled study

  • Urology – Original Paper
  • Published:
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Abstract

Purpose

We studied the effect of a platelet-rich fibrin matrix (PRFM) combined with prostaglandin E-1 (PGE-1) injection on erectile function in patients refractory to response for phosphodiesterase type 5 inhibitors (PDE5-Is).

Methods

This randomized, double-blind, placebo-controlled study included 80 patients. The patients were randomly assigned to four groups and blinded together with the administrating physicians to the nature of the intracorporeal injection (ICI) therapies. Group (1) received saline, group (2) received platelet-rich fibrin matrix (PRFM), group (3) received prostaglandin E-1 (PGE-1), and group (4) received a combination of PRFM + PGE-1. The patients received ICI therapy weekly for 8 consecutive weeks. Clinical information and follow-up data were obtained at 1, 2, 3, and 6 months.

Results

A significant increase occurred in the validated Arabic version of the International Index of Erectile Function (ArIIEF-5) score in group (4) compared to the other three groups (p value = 0.037). There was a significant difference in erection hardness scale (EHS) scores among all groups after receiving the different treatments (p = 0.004). A significant increase was seen in the ArIIEF-5 score in groups 4 and 3 compared to that in groups 1 and 2 (p < 0.001). There was also a significant increase in the arterial dilatation % in groups 4 and 3 compared to that in groups 1 and 2 (p = 0.019).

Conclusion

The combination of PRFM plus PGE-1 had shown significant improvement in the ArIIEF-5 score, yet the patients still had mild to moderate ED.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

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Authors and Affiliations

  1. Department of Andrology, Sexology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt

    Adham Zaazaa, Mohamed Abbas Eid, Sameh Fayek GamalEl Din, Ashraf Zeidan, Mohamed Abdel Fattah Farag, Ahmed Fawzy & Amr Kaddah

  2. Egypt Ministry of Health and Population, Cairo, Egypt

    Ahmed AbdEl Hakeem

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  1. Adham Zaazaa
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  2. Mohamed Abbas Eid
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  3. Sameh Fayek GamalEl Din
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  7. Ahmed Fawzy
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Contributions

AZ and MA: developed the concept and study design. SFGD: drafted the manuscript. AZ, AH, MF, AF, and AK: recruited the cases and performed the statistics of the study. All authors approved the final manuscript.

Corresponding author

Correspondence to Sameh Fayek GamalEl Din.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the local ethical committee.

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Informed consent was obtained from all individual participants included in the study.

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Zaazaa, A., Eid, M.A., GamalEl Din, S.F. et al. Evaluation of platelet-rich fibrin matrix combined with PGE-1 injection on erectile function in patients with refractory response to PDE5-I: a randomized placebo-controlled study. Int Urol Nephrol (2024). https://doi.org/10.1007/s11255-024-04139-w

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