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Dermatologic surgeons’ approaches to acral lentiginous melanoma: a survey of the American College of Mohs Surgery
Acral lentiginous melanoma (ALM) is a subtype of melanoma that primarily affects ethnic minorities and is associated with poor outcomes. Racial...
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Trends by race and ethnicity in incidence and mortality of acral lentiginous melanoma: analysis of Surveillance, Epidemiology, and End Results 2000–2020
Limited data describe the epidemiology and risk factors of acral lentiginous melanoma (ALM). In this retrospective analysis, we examined trends in...
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A novel survival nomogram for stage I-III acral lentiginous melanoma patients, based on the SEER database and a multi-center external validation cohort
PurposeTo construct an effective prognostic nomogram for patients with clinically localized Acral lentiginous melanoma (ALM).
Methods ...
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ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of cutaneous melanoma (CM), and...
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Refining the application of PRAME—a useful marker in high CSD and acral melanoma subtypes
Pathologic discordance affecting patient management may approach 20% in melanocytic cases following specialist review. The diagnostic utility of...
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Epidemiology and characteristics of acral lentiginous melanoma compared to lentigo melanoma in France: a multicentric retrospective study from the French cohort RIC-Mel database
BackgroundSkin phototype, latitude and sun exposure are classic risk factors for melanomas but are not relevant to acrolentiginous melanomas (ALM)....
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Surgical resection margin for T3–T4 primary acral melanoma: a multicenter retrospective cohort study
Although the National Comprehensive Cancer Network (NCCN) guidelines include clear recommendations for the appropriate resection margins in non-acral...
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Develo** skin cancer education materials for darker skin populations: crowdsourced design, message targeting, and acral lentiginous melanoma
Despite decreased susceptibility, darker skin individuals who develop melanoma have worse survival. This disparity in melanoma mortality is the...
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Caucasians with acral lentiginous melanoma have the same outcome as patients with stage- and limb-matched superficial spreading melanoma
PurposeAcral lentiginous melanoma (ALM), a relatively rare subtype of cutaneous melanoma, has been reported to have a worse prognosis than other...
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Epidemiology and Prognostic Factors of Malignant Melanoma Among 200 Asian Patients from a Single Medical Center
With the prevalence of malignant melanoma increasing gradually and the progressive westernization of the Asian lifestyle, it is important to analyze...
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Prognostic significance of acral lentiginous histologic type in T1 melanoma
Acral lentiginous melanoma (ALM) is a rare type of cutaneous melanoma with a poor prognosis. It is unclear whether the poor outcome of ALM is due to...
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TERT amplification but not activation of canonical Wnt/β-catenin pathway is involved in acral lentiginous melanoma progression to metastasis
Acral lentiginous melanoma (ALM) is a rare tumor that occurs on non-sun exposed skin areas of the hands and feet. Reports suggest that ALM exhibits...
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CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort
BackgroundCCND1 copy number increase is characteristic of acral melanoma and is useful in distinguishing benign and malignant acral melanocytic...
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Prognostic Significance of Primary Tumor-Infiltrating Lymphocytes in a Contemporary Melanoma Cohort
BackgroundThe prognostic impact of tumor-infiltrating lymphocytes (TILs) on outcomes and treatment efficacy for patients with melanoma in the...
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Identification of fusions with potential clinical significance in melanoma
Though uncommon in melanoma, gene fusions may have therapeutic implications. Next generation sequencing-based clinical assays, designed to detect...
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Lower limb cutaneous melanoma surgery: location matters
The anatomical location of cutaneous melanoma is a relevant independent prognostic factor in melanoma. The aim of the study is to know the prognosis...
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Management of Localized Melanoma in the Anti-PD-1 Era
Purpose of ReviewThe management of cutaneous melanoma has rapidly progressed over the past decade following the introduction of effective systemic...
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Unveiling Melanoma: A Deep Dive into Disparities at a Latin-American Cancer Institute
IntroductionThe worldwide incidence of melanoma has increased in the last 40 years. Our aim was to describe the clinic-pathological characteristics...
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