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Nano-chitosan/bovine lactoperoxidase and lactoferrin formulation modulates the hepatic deterioration induced by 7,12-dimethylbenz[a]anthracene
Lactoperoxidase (LPO) and lactoferrin (LF) are promising bovine proteins that can be nano-formulated with chitosan nanoparticles giving a potent...
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Oral administration of tartrazine (E102) accelerates the incidence and the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced breast cancer in rats
BackgroundDespite the considerable advances made in the treatment of cancer, it remains a global threat. Tartrazine (E102) is a synthetic dye widely...
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Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer
Mammary cancer, or breast cancer in women, is a polygenic disease with a complex etiopathogenesis. While much remains elusive regarding its origin,...
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New fluorobenzamidine exerts antitumor activity against breast cancer in mice via pro-apoptotic activity
BackgroundBreast cancer is one of the leading causes of cancer-related morbidities. The present study aimed to evaluate the efficacy of...
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Bcl-2 Interacts with Beclin 1 and Regulates Autophagy in 7, 12-Dimethylbenz[a]anthracene-Induced Hamster Buccal-Pouch Squamous-Cell Tumorigenesis
ObjectiveAutophagy is a programmed cell death procedure, which has essential functions in tumorigenesis. However, its temporal expression and...
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Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A
PurposeOkadaic acid class of tumor promoters are transformed into endogenous protein inhibitors of PP2A, SET, and CIP2A in human cancers. This...
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Evaluating antitumor activity of antiglypican-3 therapy in experimentally induced skin cancer in mice
AbstractGlypican-3 (GPC3) is considered as a cell surface heparan sulfate proteoglycan. It is overexpressed in skin cancer and promotes tumor...
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Lymphatic Drainage System and Lymphatic Metastasis of Cancer Cells in the Mouse Esophagus
BackgroundLymphatic metastasis is commonly seen in patients with esophageal squamous cell carcinoma (ESCC). Both lymphatic metastasis and the number...
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Enhanced DNA-repair capacity and resistance to chemically induced carcinogenesis upon deletion of the phosphatase regulator NIPP1
Nuclear Inhibitor of PP1 (NIPP1) is a conserved regulatory subunit of protein phosphatase PP1. The selective deletion of NIPP1 in mouse liver...
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Tibolone and Breast Tissue: a Review
The safety profile of hormone replacement therapy (HRT) on breast is still controversial. Tibolone is an option of treatment for climacteric syndrome...
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Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
BackgroundαB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a...
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Establishment of an optimized orthotopic bladder cancer model in mice
BackgroundBladder cancer (BC) is one of the most common malignancies of the genitourinary system. Animal models offer an important tool to explore...
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Toxicity study of di(2-ethylhexyl)phthalate (DEHP) administration on reproductive parameters in male albino rats
Di(2-ethylhexyl)phthalate (DEHP)-administration was found to be toxic in mammalian systems and also known to affect the male reproduction in rats....
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A Method to Pre-Screen Rat Mammary Gland Whole-Mounts Prior To RNAscope
RNAscope is a quantitative in situ gene expression measurement technique that preserves the spatial aspect of intact tissue; thus, allowing for...
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Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation
Interleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such...
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Role of Fyn in hematological malignancies
BackgroundTyrosine kinase Fyn is a member of the Src family of kinases. In addition to the wild type, three mRNA splice isoforms of Fyn have been...
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Anti-proliferative activity of Artemisia marschalliana on cancerous cell lines
BackgroundThe genus Artemisia of the Asteraceae family has different species that are used in the treatment of a wide range of diseases, including...
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The Gut Microbiome and Hepatocellular Carcinoma
The microbiome modulates key processes in metabolism, inflammation, and immunity and plays pivotal roles in many gastrointestinal and liver diseases....
