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Remarkable histopathological improvement of experimental toxoplasmosis after receiving spiramycin-chitosan nanoparticles formulation
The present study investigated the anti-Toxoplasma effect of chitosan nanoparticles [CS NPs], spiramycin, spiramycin co-administered with...
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Acquired WT1 mutations contribute to relapse of NPM1-mutated acute myeloid leukemia following allogeneic hematopoietic stem cell transplant
The role of WT1 protein in hematopoiesis and leukemogenesisis incompletely elucidated. WT1 overexpression is common in acute myeloid leukemia (AML);...
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Current status and future perspectives in targeted therapy of NPM1-mutated AML
Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is predominantly located in the nucleolus and exerts multiple functions,...
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Meta-analysis of reported presacral myelolipomas, including a report of a new case
BackgroundPresacral myelolipomas form a rare disease and are often found incidentally in imaging diagnostics.
Case presentationIn this study, we...
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The discrepancy of antemortem clinical diagnosis and postmortem autopsy diagnosis of lung pathologies in under-five deaths and the reasons for discrepancies: a case series analysis
BackgroundDiagnostic autopsy is the most reliable approach to definitively ascertain the cause of death and evaluate the accuracy of antemortem...
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GK-1 effectively reduces angiogenesis and prevents T cell exhaustion in a breast cancer murine experimental model
Breast cancer is the leading malignancy in women worldwide, both in terms of incidence and mortality. Triple-negative breast cancer (TNBC) is the...
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Nelarabine-containing salvage therapy and conditioning regimen in transplants for pediatric T-cell acute lymphoblastic leukemia and lymphoma
Therapy for relapsed or refractory (r/r) T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) in children is...
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Highlighting the role of long non-coding RNA (LncRNA) in multiple myeloma (MM) pathogenesis and response to therapy
Transcripts longer than 200 nucleotides that are not translated into proteins are known as long non-coding RNAs, or lncRNAs. Now, they are becoming...
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Management of Myelofibrosis-Associated Anemia: Focus on Standard Agents and Novel Therapeutics in Phase 3 Clinical Trials
Purpose of ReviewThe management of myelofibrosis is risk-adapted when considering transplant eligibility and symptom-directed, prioritizing the most...
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The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants
BackgroundEarly detection of biliary atresia (BA) is a great challenge providing the main useful way to improve its clinical consequence. Promising...
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Dual targeting of JAK2 and ERK interferes with the myeloproliferative neoplasm clone and enhances therapeutic efficacy
Myeloproliferative neoplasms (MPN) show dysregulated JAK2 signaling. JAK2 inhibitors provide clinical benefits, but compensatory activation of MAPK...
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Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice
Precise regulation of chromatin architecture is vital to physiological processes including hematopoiesis. ARID1A is a core component of the mammalian...
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Primary extramedullary plasmacytoma with diffuse lymph node involvement: a case report and review of the literature
BackgroundPrimary plasmacytomas are localized proliferations of clonal plasma cells occurring in the absence of a systemic plasma cell dyscrasia such...
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Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche
Inflammation in the bone marrow (BM) microenvironment is a constitutive component of leukemogenesis in acute myeloid leukemia (AML). Current evidence...
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Stroma-derived neoplasms and pseudoneoplastic lesions of the spleen: a select review of pathologic and CT/MRI findings
A wide spectrum of benign and malignant primary mesenchymal tumors and tumor-like lesions of the spleen has been recently included under the umbrella...
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Cytokine levels in patients with non-M3 myeloid leukemia are key indicators of how well the disease responds to chemotherapy
Acute myeloid leukemia (AML) is a malignant hematological neoplastic disease. Autocrine or paracrine cytokines released by leukemic cells regulate...
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Mouse models of systemic juvenile idiopathic arthritis and macrophage activation syndrome
Macrophage activation syndrome (MAS) is a life-threatening complication of pediatric rheumatic diseases, occurring most commonly in children with...
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Acute mast cell leukemia without KIT D816V mutation and lack of CD2 and CD25—a case report of rare entity
Systemic mastocytosis (SM) is a rare hematological neoplasm caused by the excessive proliferation of pathological mast cells that accumulate in the...
