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Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial
BackgroundKetone monoester β-hydroxybutyrate (KEβHB) ingestion has emerged as an effective method of inducing acute ketosis. Although evidence...
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Pemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver disease
Estrogen receptor (ER) antagonists, such as tamoxifen and toremifene, are widely used as adjuvant therapies for ER-positive breast cancer. These...
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The Ketogenic Diet and Alzheimer’s Disease
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common form of dementia. There are currently...
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Analysis of the relationship of refractory gout between potential biomarkers and diet structure and lifestyle based on 1H-NMR
ObjectiveWe investigated the different life styles among the diet structures and exercise patterns of 100 patients with refractory gout and 79...
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A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease
BackgroundA ketogenic diet (KD) may benefit people with neurodegenerative disorders marked by mitochondrial depolarization/insufficiency, including...
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Biomarker profiling of postmortem blood for diabetes mellitus and discussion of possible applications of metabolomics for forensic casework
Acute metabolic disorders of diabetes mellitus (DM), such as diabetic ketoacidosis, hyperosmolar hyperglycemic state, and hypoglycemia, are...
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Ketosis in patients undergoing medically supervised therapeutic fasting—results from an observational trial
Background/aimMedically supervised fasting has long tradition and broad acceptance in some European countries. The exact amount to which ketone...
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A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma
BackgroundAnimal brain-tumor models have demonstrated a synergistic interaction between radiation therapy and a ketogenic diet (KD). Metformin has...
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The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum
BackgroundWe aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in...
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Analysis of fecal microbiome and metabolome changes in goats with pregnant toxemia
BackgroundPregnancy toxemia is a common disease, which occurs in older does that are pregnant with multiple lambs in the third trimester. Most of the...
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Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients
BackgroundRecent evidence suggests a potentially protective effect of increasing ketone body availability via accepting low macronutrient intake...
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Hypoketotic hypoglycemia in citrin deficiency: a case report
BackgroundCitrin deficiency (CD) is a recessive metabolic disease caused by biallelic pathogenic variants in SLC25A13 . Although previous studies...
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3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
3-Hydroxybutyrate (3HB) is a small ketone body molecule produced endogenously by the body in the liver. Previous studies have shown that 3HB can...
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Searching molecular biomarkers correlating with BSID-III at 24 months in infants with neonatal hypoxic-ischemic encephalopathy
An early prediction of outcomes of neonatal hypoxic-ischemic encephalopathy (NE) is of key importance in reducing neonatal mortality and morbidity....
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Differential ketogenic diet-induced shift in CSF lipid/carbohydrate metabolome of pediatric epilepsy patients with optimal vs. no anticonvulsant response: a pilot study
BackgroundThe low carbohydrate, high fat ketogenic diet can be an effective anticonvulsant treatment in some pediatric patients with...
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Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study...
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A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with early-stage type 2 diabetes: the ASSET study
BackgroundWhile the cardioprotective benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors have been established in patients with...
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Development of a hyperosmolar-hyperglycemic state and possible fulminant type 1 diabetes mellitus during the treatment of a case of adenocarcinoma of the lung and interstitial pneumonia
An 85-year-old man was being treated with anti-cancer drugs for adenocarcinoma of the lung and was on a tapering dose of prednisolone for...
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SGLT2 Inhibition by Dapagliflozin Attenuates Diabetic Ketoacidosis in Mice with Type-1 Diabetes
BackgroundSGLT2 inhibitors increase plasma ketone concentrations. It has been suggested that insulinopenia, along with an increase in the...
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Non-autoimmune acute-onset type 1 diabetes mellitus newly developed in an elderly patient presenting elevation of serum pancreatic exocrine enzymes
An 82 year-old female patient not suffering from diabetes was transported to our hospital with hyperglycemia (HbA1c 8.2%, blood glucose 584 mg/dL)...
