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Applications and prospects of cryo-EM in drug discovery
Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it...
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Modulation of neuroinflammation and oxidative stress by targeting GPR55 – new approaches in the treatment of psychiatric disorders
Pharmacological treatment of psychiatric disorders remains challenging in clinical, pharmacological, and scientific practice. Even if many different...
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Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis
Drug resistance and poor treatment response are major obstacles to the effective treatment of acute myeloid leukemia (AML). A deeper understanding of...
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Tumor Pre-Targeting System Using Streptavidin-Expressing Bacteria
PurposeA major obstacle to targeted cancer therapy is identifying suitable targets that are specifically and abundantly expressed by solid tumors....
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Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing...
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Drug-tolerant persister cells in cancer: the cutting edges and future directions
Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-resistant bacterial biofilms. Similar populations with...
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Microglia in neuroimmunopharmacology and drug addiction
Drug addiction is a chronic and debilitating disease that is considered a global health problem. Various cell types in the brain are involved in the...
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PI3K/AKT/mTOR inhibitors as potential extracellular matrix modulators for targeting EMT subtype gastric tumors
Targeting the extracellular matrix (ECM) is considered as a promising strategy in cancer therapeutics. This study was designed to identify the...
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Preventing incubation of drug craving to treat drug relapse: from bench to bedside
In 1986, Gawin and Kleber reported a progressive increase in cue-induced drug craving in individuals with cocaine use disorders during prolonged...
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Targeting ATR in patients with cancer
Pharmacological inhibition of the ataxia telangiectasia and Rad3-related protein serine/threonine kinase (ATR; also known as FRAP-related protein...
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Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance
The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between...
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Network-based drug repurposing for schizophrenia
Despite recent progress, the challenges in drug discovery for schizophrenia persist. However, computational drug repurposing has gained popularity as...
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BCMA-targeting chimeric antigen receptor T cell therapy for relapsed and/or refractory multiple myeloma
Recently, many new therapies have improved the outcomes of patients with relapsed and/or refractory multiple myeloma (RRMM). Nevertheless, recurrence...
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Anesthetic drug discovery with computer-aided drug design and machine learning
Computer-aided drug design (CADD) has emerged as a highly effective and indispensable tool for streamlining the drug discovery process, leading to...
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Targeting efficacy and anticancer activity of polymeric nanoparticles of SN-38 on colon cancer cell lines
BackgroundColorectal cancer is the third most prevailing cancer in the whole world. Chemotherapeutic agents which are used for treatment have severe...
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Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy
PurposeMalignant cerebral tumors have poor prognosis and the blood–brain barrier is a major hindrance for most drugs to reach those tumors. Lipid...
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Integrated systems biology analysis of acute lymphoblastic leukemia: unveiling molecular signatures and drug repurposing opportunities
Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by aberrant proliferation and accumulation of lymphoid precursor cells...
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Long–Term Outcome After Discontinuation of CGRP-Targeting Therapy for Migraine
Purpose of reviewCalcitonin gene-related peptide (CGRP)-targeting agents are potential candidates for disease-modifying migraine drugs. However, most...
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Targeting cancer stem cells as a strategy for reducing chemotherapy resistance in head and neck cancers
PurposeResistance to chemotherapy and radiotherapy is the primary cause of a poor prognosis in oncological patients. Researchers identified many...
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Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies
Despite recent advancements in the diagnosis and treatment of breast cancer (BC), patient outcomes in terms of survival, recurrence, and disease...
