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Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins
BackgroundPrevious studies have determined the epigenetic association between DNA methylation and pulmonary function among various ethnics, whereas...
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DNA methylation and cancer: transcriptional regulation, prognostic, and therapeutic perspective
DNA methylation is one among the major grounds of cancer progression which is characterized by the addition of a methyl group to the promoter region...
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DNA methylation of ELOVL2 gene as an epigenetic marker of age among Egyptian population
BackgroundCellular and molecular changes occur during aging, decreasing organ function. The aging process was measured by several biomarkers,...
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Correlation of DNA methylation of DNMT3A and TET2 with oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Abnormal epigenetic modifications, including DNA methylation, are...
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Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors
PurposeLiquid biopsy of cyst fluid in brain tumors has not been extensively studied to date. The present study was performed to see whether...
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Non-coding RNA-mediated endothelial-to-mesenchymal transition in human diabetic cardiomyopathy, potential regulation by DNA methylation
AimsDiabetic cardiomyopathy (DCM) is a major complication of diabetes and a risk factor for cardiovascular disease. Endothelial dysfunction is...
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Analysis of age-dependent DNA methylation changes in plucked hair samples using massive parallel sequencing
The analysis of age-dependent DNA methylation changes is a valuable tool in epigenetic research and forensic genetics. With some exceptions, most...
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Integrative analysis with machine learning identifies diagnostic and prognostic signatures in neuroblastoma based on differentially DNA methylated enhancers between INSS stage 4 and 4S neuroblastoma
IntroductionAccumulating evidence demonstrates that aberrant methylation of enhancers is crucial in gene expression profiles across several cancers....
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Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently,...
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Seminal cell–free DNA as a potential marker for in vitro fertility of Nellore bulls
PurposeThis study aimed to identify a marker for freezability and in vitro fertility of sperm samples before freezing.
MethodsSemen was collected...
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Oocyte Vitrification Reduces its Capability to Repair Sperm DNA Fragmentation and Impairs Embryonic Development
Oocytes play a crucial role in repairing sperm DNA damage, which can affect the next generation; however, certain factors can impair this ability....
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Morphological and molecular analysis of Isoparorchis trisimilitubis from catfish in Northeast India on the basis of nuclear and mitochondrial DNA
Isoparorchis is an endoparasite of fish that is found in the swim bladder of Wallago attu . Isoparorchis is predominant in Asian countries, Russia and...
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DNA methylation profiles in urothelial bladder cancer tissues and children with schistosomiasis from Eggua, Ogun State, Nigeria
BackgroundSquamous cell carcinoma has been attributed to chronic schistosomiasis and is the predominant type of bladder cancer in schistosomiasis...
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Utility of blood as the clinical specimen for the diagnosis of ocular toxoplasmosis using uracil DNA glycosylase-supplemented loop-mediated isothermal amplification and real-time polymerase chain reaction assays based on REP-529 sequence and B1 gene
BackgroundOcular infection with Toxoplasma gondii is a major preventable cause of blindness, especially in young people. The aim of the present...
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DNA as the main target in radiotherapy—a historical overview from first isolation to anti-tumour immune response
DNA damage is one of the foremost mechanisms of irradiation at the biological level. After the first isolation of DNA by Friedrich Miescher in the...
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Authentication of milk thistle commercial products using UHPLC-QTOF-ESI + MS metabolomics and DNA metabarcoding
BackgroundMilk thistle is one of the most popular hepatoprotectants, and is often sold in combination with other ingredients. Botanical supplements...
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Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)
PurposeGlioblastoma (GBM) stands out as the most prevalent and aggressive intracranial tumor, notorious for its poor prognosis. The current...
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Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer
BackgroundDiverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation...
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Suspected twin anemia polycythemia sequence in a dichorionic, diamniotic twin pregnancy: a case report
BackgroundTwin anemia polycythemia sequence is a rare complication in monochorionic twin pregnancy.
Case presentationWe describe a case of...
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The impact of DNA methylation as a factor of Adverse Pregnancy and Birth Outcomes (APBOs): a systematic review protocol
BackgroundDeoxyribonucleic acid (DNA) methylation is one of the epigenetic modifications that has gained a lot of interest as a factor influencing...
