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Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies
Apoptosis, the process of programmed cell death, occurs normally during development and aging. Members of the B-cell lymphoma 2 (BCL2) family of...
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Recent advances in understanding the biology of follicular lymphoma
Follicular lymphoma (FL), the most common indolent B-cell lymphoma, develops over decades before manifesting as overt disease. BCL2 overexpression by...
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L-carnitine ameliorates toxic effect of short- and long-time use of buprenorphine on male reproductive system in a rat model
Stress-oxidative-induced sexual dysfunction has been widely reported to be associated with drug use disorders, particularly buprenorphine (Bu). This...
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Simplified algorithm for genetic subty** in diffuse large B-cell lymphoma
Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole...
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Uterine smooth muscle tumors of uncertain malignant potential: a retrospective evaluation of clinical pathology and immunohistochemistry features
BackgroundUterine smooth muscle tumor of uncertain malignant potential (STUMP) is a group of uterine smooth muscle tumors which cannot be classified...
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Evaluation of the cytotoxic activities of the essential oil from Pistacia atlantica Desf. oleoresin on human gastric cancer cell lines
Numerous herbal products have been the subject of research regarding their potential role in cancer prevention or adjuvant therapy. Pistacia atlantica ...
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BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia
BackgroundBCL2 protein inhibitor venetoclax (ABT-199) has been authorized by Food and Drug Administration for relapsed/refractory chronic lymphoid...
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Aggressive B-cell non-Hodgkin lymphomas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology
Aggressive B-cell non-Hodgkin lymphomas are a heterogeneous group of diseases and our concepts are evolving as we learn more about their clinical,...
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STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer
BackgroundSTAT3 plays an important role in cervical cancer. LC3B, the most potential molecular biomarker of autophagy that may promote or inhibit...
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In vitro anticancer activity of hydatid cyst fluid on colon cancer cell line (C26)
BackgroundColon cancer is the third most common cancer and the fourth leading cause of death from cancer. Some parasites are introduced as an...
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The effect of two types of diet on apoptosis indexes, lipid profile and histopathological outcome in acute kidney injury during exercise
BackgroundExercise and some pre-AKI diets have been shown to improve injury, apoptosis, and lipid profile. In this study, the effect of two different...
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Male obesity is associated with sperm telomere shortening and aberrant mRNA expression of autophagy-related genes
BackgroundObesity is regarded a global public health crisis. It has been implicated in a variety of health problems, but when it comes to male...
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Prevalence of IRF4 rearrangement in large B-cell lymphomas of the Waldeyer’s ring in adults
Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma (B-NHL) in adults. These lymphomas are classified according to...
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ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides
Myelomonocytic and monocytic acute myeloid leukemia (AML) subtypes are intrinsically resistant to venetoclax-based regimens. Identifying targetable...
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Chronic Lymphocytic Leukemia: Time-Limited Therapy in the First-Line Setting and Role of Minimal Residual Disease
Purpose of ReviewIn this review, we provide an overview of different time-limited combination therapies of chronic lymphocytic leukemia (CLL) and...
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Waldenström Macroglobulinemia: Targeted Agents Taking Center Stage
With the worldwide approval of the oral covalent Bruton tyrosine kinase (BTK) inhibitors ibrutinib and zanubrutinib for treating patients with...
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Dexmedetomidine ameliorates x-ray-induced myocardial injury via alleviating cardiomyocyte apoptosis and autophagy
BackgroundRadiotherapy is a primary local treatment for tumors, yet it may lead to complications such as radiation-induced heart disease (RIHD)....
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PHF6 maintains acute myeloid leukemia via regulating NF-κB signaling pathway
Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the accumulation of immature and abnormally differentiated myeloid...
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Inhibition of LINC00958 hinders the progression of osteoarthritis through regulation of the miR-214-3p/FOXM1 axis
ObjectiveWe investigated the impact of the long noncoding RNA LINC00958 on cellular activity and oxidative stress in osteoarthritis (OA).
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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma
More than 85% of patients with uveal melanoma (UM) carry a GNAQ or GNA11 mutation at a hotspot codon (Q209) that encodes G protein α subunit q/11...