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Potential Implications of Slowing Disease Progression in Amyloid-Positive Early Alzheimer’s Disease: Estimates from Real-World Data
BackgroundEmerging therapies have shown promising results for slowing the progression of Alzheimer’s disease (AD). However, the potential impact of...
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High frequency of MEFV disease-causing variants in children with very-early-onset inflammatory bowel disease
BackgroundBiological similarities between inflammatory bowel disease (IBD) and familial Mediterranean fever (FMF) have been described in humans and...
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Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson’s disease
PurposeThe specific characteristics of autonomic involvement in patients with early Parkinson’s disease (PD) are unclear. This study aimed to...
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Cardiovascular disease risk in early rheumatoid arthritis: the impact of cartilage oligomeric matrix protein (COMP) and disease activity
BackgroundTo investigate whether baseline serum cartilage oligomeric matrix protein (COMP), patient characteristics, traditional cardiovascular...
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Patients’ experiences undergoing breast evaluation in Rwanda’s Women’s Cancer Early Detection Program
PurposeThere is urgent need for interventions to facilitate earlier diagnosis of breast cancer in low- and middle-income countries where mammography...
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Diagnosis to dissection: AI’s role in early detection and surgical intervention for gastric cancer
Gastric cancer remains a formidable health challenge worldwide; early detection and effective surgical intervention are critical for improving...
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Early prediction of Alzheimer's disease using convolutional neural network: a review
In this paper, a comprehensive review on Alzheimer's disease (AD) is carried out, and an exploration of the two machine learning (ML) methods that...
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Identification and management of subclinical disease activity in early multiple sclerosis: a review
ImportanceEarly treatment initiation in multiple sclerosis (MS) is crucial in preventing irreversible neurological damage and disability progression....
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Detection and prediction of freezing of gait with wearable sensors in Parkinson’s disease
Freezing of gait (FoG) is one of the most distressing symptoms of Parkinson’s Disease (PD), commonly occurring in patients at middle and late stages...
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Early and Accurate Detection of Radiation-induced Heart Damage by Cardiodynamicsgram
Cardiodynamicsgram (CDG) has emerged recently as a noninvasive spatiotemporal electrocardiographic method for subtle cardiac dynamics information...
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Advances in far-infrared research: therapeutic mechanisms of disease and application in cancer detection
Far infrared (FIR) irradiation is commonly used as a convenient, non-contact, non-invasive treatment for diseases such as myocardial ischemia,...
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Significance of transthoracic ultra-sonography in early detection of patients with interstitial lung diseases in Aswan University Hospital
BackgroundRecently, the diagnosis and follow-up of numerous pulmonary diseases such as pneumothorax, pneumonia, and pleural effusion were easily by...
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Early detection of anthracycline-induced cardiotoxicity using [68 Ga]Ga-FAPI-04 imaging
PurposeAnthracycline-induced cardiotoxicity (AIC), whose major manifestation is diffuse myocardial fibrosis, is an important clinical problem in...
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Deep transfer learning with fuzzy ensemble approach for the early detection of breast cancer
Breast Cancer is a significant global health challenge, particularly affecting women with higher mortality compared with other cancer types. Timely...
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Guidelines for clinical evaluation of chronic kidney disease in early stages
BackgroundFor the development of pharmaceutical products in kidney field, appropriate surrogate endpoints which can predict long-term prognosis are...
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Digital oral health biomarkers for early detection of cognitive decline
BackgroundOral health could influence cognitive function by stimulating brain activity and blood flow. The quantified oral status from oral...
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Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy
PurposeCancer treatment with alpha-emitter-based radioligand therapies (α-RLTs) demonstrates promising tumor responses. Radiolabeled peptides are...
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Role of fibroblast growth factor-23 as an early marker of metabolic bone disease of prematurity
PurposeMetabolic bone disease of prematurity (MBDP) remains a significant cause of morbidity in extremely premature newborns. In high-risk patients,...
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Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage
ObjectivePrevious research indicates a link between cognitive impairment and chronic kidney disease (CKD), but the underlying factors are not fully...
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Evaluation of the application of sequence data to the identification of outbreaks of disease using anomaly detection methods
Anomaly detection methods have a great potential to assist the detection of diseases in animal production systems. We used sequence data of Porcine...
