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The factors that are associated with itching in chronic kidney patients and evaluation of itching with the 5d itch scale
ObjectiveUremic pruritus is a distressing complication of chronic kidney disease (CKD), associated with mortality, and negatively impacts quality of...
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Pruritus Ani—Not an Itch that Can Be Ignored
Despite its prevalence and suspected neoplastic associations, pruritus ani is a condition that is both under-reported and under-researched. There is...
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IL-31, itch and hematological malignancies
Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and...
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Psychodermatology of Chronic Pruritus: An Overview of the Link Between Itch and Distress
Chronic pruritus (CP) is defined as an unpleasant sensation causing a desire to scratch and lasting > 6 weeks. It has a multifactorial etiology but...
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Hypnotherapy for procedural pain, itch, and state anxiety in children with acute burns: a feasibility and acceptability study protocol
BackgroundBurns and related procedures are painful and distressing for children, exposing them to acute and chronic sequelae that can negatively...
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Chronic itch in African Americans: an unmet need
Chronic pruritus carries a significant burden of disease and is associated with a negative impact on quality of life. African Americans are...
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Improvements in itch and sleep following treatment with baricitinib in combination with topical corticosteroids are associated with better quality of life and productivity in adult patients with moderate-to-severe atopic dermatitis: a post hoc analysis from BREEZE-AD7
BackgroundTreatment with baricitinib in combination with topical corticosteroids previously showed greater improvements in itch and sleep versus...
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Psychometric properties of the itch numeric rating scale, skin pain numeric rating scale, and atopic dermatitis sleep scale in adult patients with moderate-to-severe atopic dermatitis
BackgroundThe Itch Numeric Rating Scale (NRS), Skin Pain NRS, and Atopic Dermatitis Sleep Scale (ADSS) are self-administered patient-reported outcome...
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Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus
BackgroundChronic kidney disease-associated pruritus (CKD-aP) is characterized by persistent itch that often leads to substantially impaired quality...
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A real-world study of the longitudinal course of itch severity and frequency in adults with atopic dermatitis
Itch is a complex symptom that is both common and burdensome in atopic dermatitis (AD). Yet, little is known about the longitudinal course of itch in...
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Itch and Sleep Improvements with Baricitinib in Patients with Atopic Dermatitis: A Post Hoc Analysis of 3 Phase 3 Studies
IntroductionBurdensome symptoms of atopic dermatitis include itch and sleep disturbance. This post hoc analysis reports the effect of baricitinib on...
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Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review
H-1 antihistamines are commonly used in dermatological practice for itch and urticaria control. The widespread expression of H-1 receptor on...
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Itch in Organs Beyond the Skin
Purpose of ReviewThe purpose of this review was to explore mechanisms, causes, and therapies of itchy conditions involving organs beyond the skin...
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Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis
BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease accompanied with itchy and scaly rash. Compound traditional Chinese medicine...
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Use of Butorphanol as Treatment for Cholestatic Itch
BackgroundPruritus is a debilitating symptom of cholestatic diseases such as primary biliary cholangitis and primary sclerosing cholangitis and often...
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Itch in Children with Type 1 Diabetes: A Cross-Sectional Study
IntroductionType 1 diabetes (T1D) is reported to be one of the most common medical conditions in school-age youth and is ranked third in the...
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Relationship between pruritus and sleep in participants with primary biliary cholangitis in the Phase 2b GLIMMER trial
BackgroundCholestatic pruritus and fatigue are debilitating conditions associated with primary biliary cholangitis (PBC) and can significantly impact...
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Pregabalin for postherpetic itch: a case report
BackgroundPostherpetic itch has not commonly received attention as a complication of herpes zoster because pain predominates over itch in most...
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NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX
NORE1A (RASSF5) is a tumor suppressor of the Ras-association domain family (RASSF) that is commonly inactivated in multiple human cancers. However,...
