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P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction
Emergency hematopoiesis is the driving force of the inflammatory response to myocardial infarction (MI). Increased proliferation of hematopoietic...
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Newly diagnosed isolated myeloid sarcoma–paired NGS panel analysis of extramedullary tumor and bone marrow
Isolated myeloid sarcoma (MS) is a rare malignancy in which myeloid blast forms tumors at various locations while the bone marrow (BM) remains...
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Choristoma: a very rare cause of thyroid nodule. Case report and literature review
BackgroundChoristoma is a well-defined benign lesion formed by histologically normal tissue in an unusual location. Diagnosis is confirmed after...
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Impact of genotype on multi-organ iron and complications in patients with non-transfusion-dependent β-thalassemia intermedia
We evaluated the impact of the genotype on clinical and hematochemical features, hepatic and cardiac iron levels, and endocrine, hepatic, and...
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Systemic administration of STING agonist promotes myeloid cells maturation and antitumor immunity through regulating hematopoietic stem and progenitor cell fate
STING is a pivotal mediator of effective innate and adaptive anti-tumor immunity; however, intratumoral administration of STING agonists have shown...
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Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice
IntroductionPrimary myelofibrosis (PMF) is a clonal stem cell disorder characterized by myeloid dominant hematopoiesis and dysregulated proliferation...
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Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice
RNA splicing and epigenetic gene mutations are the most frequent genetic lesions found in patients with myelodysplastic neoplasm (MDS). About 25% of...
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miR-29c&b2 encourage extramedullary infiltration resulting in the poor prognosis of acute myeloid leukemia
Extramedullary infiltration (EMI), as a concomitant symptom of acute myeloid leukemia (AML), is associated with low complete remission and poor...
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Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies
Hematopoiesis requires finely tuned regulation of gene expression at each stage of development. The regulation of gene transcription involves not...
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Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg
Purpose of ReviewRecently, there has been an increasing number of studies on the crosstalk between the bone and the bone marrow and how it pertains...
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Effectiveness of venetoclax and azacytidine against myeloid/natural killer cell precursor acute leukemia
Myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare leukemia subtype that possibly originates from precursor NK cells. The...
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Markedly increased small-sized megakaryocytes and platelets count in the circulation with pseudo-hyperkalemia following splenectomy
Megakaryocytes are common in the bone marrow and appear less often in circulation. Most studies on circulatory megakaryocytes have implicated...
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Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?
The bone marrow is home to well-balanced normal hematopoiesis, but also the stage of leukemia’s crime. Marrow adipose tissue (MAT) is a unique and...
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Diagnostic and Therapeutic Considerations for Extramedullary Leukemia
Purpose of ReviewThe purpose of this review is to summarize the current literature on the presentation, diagnosis, and treatment options available...
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A case of sudden hearing loss in a patient with chronic myelomonocytic leukemia
Chronic myelomonocytic leukemia is a myeloid stem cell disease characterized by an abnormal production and accumulation of monocytic cells in...
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Fat-containing pelvic lesions in females
Pelvic tumors are common in females and have a broad differential diagnosis. The clinical management of pelvic tumors varies widely—from observation...
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Renal post-mortem findings in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
Myeloproliferative neoplasms (MPN) are a heterogeneous group of hematological disorders presenting with an increased proliferation in one or several...
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Successful treatment with gilteritinib for isolated extramedullary relapse of acute myeloid leukemia with FLT3-ITD mutation after allogeneic stem cell transplantation
Acute myeloid leukemia (AML) harboring Fms-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutation is associated with shorter...
