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EBV-positive follicular lymphoma and concurrent EBV-negative diffuse large B-cell lymphoma illustrating branched evolution model and “Hit and Run” hypothesis
Epstein-Barr virus (EBV) is one of the most common viruses associated with multiple malignancies including hematopoietic, epithelial, and mesenchymal...
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Report of a semi-branched stent-graft to treat a type 1a endoleak after failed EVAR
BackgroundEndovascular techniques are advancing with the change of treatment paradigm for abdominal aortic aneurysms. Fenestrated EVAR (fEVAR) and...
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Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity
Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation landscape. Although common mutations are well-studied, little research...
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Clonal architecture evolution in Myeloproliferative Neoplasms: from a driver mutation to a complex heterogeneous mutational and phenotypic landscape
Myeloproliferative neoplasms are characterized by the acquisition at the hematopoietic stem cell level of driver mutations targeting the JAK/STAT...
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Driver mutations in ADGRL3 are involved in the evolution of ependymoma
Although there have been recent advances in the molecular pathology of ependymomas, little is known about the underlying molecular evolution during...
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Evaluation of Safety of Overhead Upper Extremity Positioning During Fenestrated–Branched Endovascular Repair of Thoracoabdominal Aortic Aneurysms
PurposePeripheral nerve and brachial plexus injury can occur from compression or stretching during positioning for operative procedures. The aim of...
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The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern
BackgroundPreterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the...
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Multi-region sequencing depicts intratumor heterogeneity and clonal evolution in cervical cancer
Cervical cancer is a heterogeneous malignancy mainly caused by human papillomavirus (HPV). While a few studies have revealed heterogeneity of...
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Features of Metabolite Changes in Disease Evolution in Cholecystolithiasis
BackgroundCholecystolithiasis is defined as a disease caused by complex and changeable factors. Advanced age, female sex, and a hypercaloric diet...
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Effect of Blood Loss and Transfusion Requirements on Clinical Outcomes of Fenestrated-Branched Endovascular Aortic Repair
ObjectiveThe aim of this study was to evaluate the effect of blood loss and transfusion requirements on clinical outcomes of patients treated by...
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Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression
The prognosis of most patients with AML is poor due to frequent disease relapse. The cause of relapse is thought to be from the persistence of...
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Malaria Therapeutic Paradigm: An Evolution Towards Commercial Drug Delivery Technology
PurposeMalaria and other parasitic infections pose serious health risks to millions of people worldwide each year. Oral medication is a crucial...
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Using Organoids to Tap Mammary Gland Diversity for Novel Insight
This article offers a comprehensive perspective on the transformative role of organoid technology on mammary gland biology research across a diverse...
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Basal Cell Carcinoma After High Dose Rate Brachytherapy: Medium-term Dermoscopic Evaluation of Cancer’s Response
IntroductionBasal cell carcinoma of the facial region remains a challenge for contemporary oncology due to the presence of aesthetic regions and...
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Tumour evolution in hepatocellular carcinoma
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically develops on the background of chronic liver disease and is an...
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Evolution of echocardiography in adult congenital heart disease: from pulsed-wave Doppler to fusion imaging
The number of patients with adult congenital heart disease (ACHD) has been dramatically increasing and adults with congenital heart disease now...
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Efficacy of endovascular repair in the treatment of retrograde ascending aortic intramural haematoma
BackgroundThe current treatment for retrograde ascending aortic intramural hematoma (RAIMH) remains challenging. This study aims to summarize the...
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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite...
