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Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
IntroductionCoexistence of acute promyelocytic leukemia and Dubin–Johnson syndrome (DJS) has not been previously reported in the literature. The...
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Spektrum renaler Nebenwirkungen neuer onkologischer Therapien
The treatment of malignant neoplasms has significantly changed in recent years and decades and the classical chemotherapeutic drugs have been...
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Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of...
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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Case Series of Angiomatoid Fibrous Histiocytoma (AFH)—A Clinico-Radiological and Pathological Conundrum
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor, common in children and young adults, often misdiagnosed as either reactive or...
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Circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers combined with clinicopathological risk has potential to better predict recurrence in stage III breast cancer treated with neoadjuvant chemotherapy: a pilot study
BackgroundThe potential value of detecting epithelial–mesenchymal transition (EMT) CTCs in early breast cancer, especially during the neoadjuvant...
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Simplifying synthesis of the expanding glioblastoma literature: a topic modeling approach
PurposeOur study aims to discover the leading topics within glioblastoma (GB) research, and to examine if these topics have “hot” or “cold” trends....
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Risk Stratification According to Baseline and Early Change in Neutrophil-to-Lymphocyte Ratio in Advanced Non-Small Cell Lung Cancer Treated with Chemoimmunotherapy: A Multicenter Real-World Study
BackgroundChemoimmunotherapy is a standard treatment for advanced non-small-cell lung cancer (NSCLC). However, data on clinical predictive factors...
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Effect of modified Baduan** exercise on nutritional status in patients with nasopharyngeal carcinoma: a randomized controlled trial
BackgroundAs a traditional Chinese fitness technique, Baduan** is a low- to medium-intensity aerobic exercise that has a common regulatory effect on...
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Health-related quality of life and symptoms of chronic myeloid leukemia patients after discontinuation of tyrosine kinase inhibitors: results from the EURO-SKI Trial
Limited data is available on the health-related quality of life (HRQoL) and symptoms of patients with chronic myeloid leukemia (CML) who are in...
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Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial
BackgroundWeight loss (WL) after gastrectomy for gastric cancer is associated with both decreased compliance with adjuvant chemotherapy and impaired...
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Mitochondrial DNA Copy Number as a Biomarker for Guiding Adjuvant Chemotherapy in Stages II and III Colorectal Cancer Patients with Mismatch Repair Deficiency: Seeking Benefits and Avoiding Harms
BackgroundColorectal cancer (CRC) patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) status are conventionally...
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Operative Therapie des Vulva- und Vaginalkarzinoms
Surgical treatment of cancer of the vulva and vagina is an important part of therapy. Complete removal of the tumour with an adequate safety margin...
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Development and validation of a scale to measure the care needs of Crohn’s disease patients: a mixed-methods study
BackgroundCrohn’s disease (CD) patients require varying levels of supportive care. In order to facilitate caregivers and nurses in precisely...
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Breaking the silence: the role of sexual communication on quality of life in women with cervical cancer
IntroductionCervical cancer (CC) and its treatments impact various dimensions of quality of life (QoL), including physical, psychological, and sexual...