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Circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers combined with clinicopathological risk has potential to better predict recurrence in stage III breast cancer treated with neoadjuvant chemotherapy: a pilot study
BackgroundThe potential value of detecting epithelial–mesenchymal transition (EMT) CTCs in early breast cancer, especially during the neoadjuvant...
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Outcome of Reconstruction with Irradiated Tumour Bone in Paediatric Malignant Bone Tumours
Reconstruction of a paediatric bone tumour after wide excision is challenging. Autologous sterilized tumour bone provides a perfect fit, avoids wear...
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Simplifying synthesis of the expanding glioblastoma literature: a topic modeling approach
PurposeOur study aims to discover the leading topics within glioblastoma (GB) research, and to examine if these topics have “hot” or “cold” trends....
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Risk Stratification According to Baseline and Early Change in Neutrophil-to-Lymphocyte Ratio in Advanced Non-Small Cell Lung Cancer Treated with Chemoimmunotherapy: A Multicenter Real-World Study
BackgroundChemoimmunotherapy is a standard treatment for advanced non-small-cell lung cancer (NSCLC). However, data on clinical predictive factors...
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Targeting chromosomal instability in patients with cancer
Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic dissemination, therapeutic resistance, and immune evasion. CIN is...
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Momelotinib versus Continued Ruxolitinib or Best Available Therapy in JAK Inhibitor-Experienced Patients with Myelofibrosis and Anemia: Subgroup Analysis of SIMPLIFY-2
IntroductionSome Janus kinase (JAK) inhibitors such as ruxolitinib and fedratinib do not address and may worsen anemia in patients with...
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Case Series of Angiomatoid Fibrous Histiocytoma (AFH)—A Clinico-Radiological and Pathological Conundrum
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor, common in children and young adults, often misdiagnosed as either reactive or...
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Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of...
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Spektrum renaler Nebenwirkungen neuer onkologischer Therapien
The treatment of malignant neoplasms has significantly changed in recent years and decades and the classical chemotherapeutic drugs have been...
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Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
IntroductionCoexistence of acute promyelocytic leukemia and Dubin–Johnson syndrome (DJS) has not been previously reported in the literature. The...
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Effect of modified Baduan** exercise on nutritional status in patients with nasopharyngeal carcinoma: a randomized controlled trial
BackgroundAs a traditional Chinese fitness technique, Baduan** is a low- to medium-intensity aerobic exercise that has a common regulatory effect on...
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Health-related quality of life and symptoms of chronic myeloid leukemia patients after discontinuation of tyrosine kinase inhibitors: results from the EURO-SKI Trial
Limited data is available on the health-related quality of life (HRQoL) and symptoms of patients with chronic myeloid leukemia (CML) who are in...
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Long-Term Effects of Oral Nutritional Supplements After Gastrectomy for Gastric Cancer: A Survival Analysis from a Multicenter, Open-Label, Randomized Controlled Trial
BackgroundWeight loss (WL) after gastrectomy for gastric cancer is associated with both decreased compliance with adjuvant chemotherapy and impaired...
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Mitochondrial DNA Copy Number as a Biomarker for Guiding Adjuvant Chemotherapy in Stages II and III Colorectal Cancer Patients with Mismatch Repair Deficiency: Seeking Benefits and Avoiding Harms
BackgroundColorectal cancer (CRC) patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) status are conventionally...