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Retro-inversion follicle-stimulating hormone peptide-modified nanoparticles for delivery of PDK2 shRNA against chemoresistant ovarian cancer by switching glycolysis to oxidative phosphorylation
BackgroundMost ovarian cancers are diagnosed at advanced stages characterized by abdominal dissemination and frequently exhibit chemoresistance....
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Bioenergetics
The field of bioenergetics deals with diverse types of energy transformation in cells; in particular, the reactions involving adenosine triphosphate...
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Potential of Bamboo in the Prevention of Diabetes-Related Disorders: Possible Mechanisms for Prevention
The therapeutic potentials of bamboo have long been recognized and have been documented in pharmacopeias around the world since 10,000 BCE. Recent...
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Enzymes
Enzymes are mostly proteins that accelerate the reaction rates. They are vital for life and execute diverse functions in the body such as: (i) aiding...
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Nanosystem-mediated lactate modulation in the tumor micro environment for enhanced cancer therapy
Metabolic reprogramming allows tumor cells to prefer aerobic glycolysis as the main energy source, resulting in the massive accumulation of lactate...
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Overview on Biological Activities of Thiazole Derivatives
In the disciplines of pharmaceutical chemistry and drug discovery process, thiazole derivatives are one of the most prominent and widely used...
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Exploring Innovative Exogenous Green Stimulus Methods for Boosting Bioprocesses: Electric, Magnetic and Ultrasound Stimulation Techniques
This book chapter provides an overview of the innovative exogenous green stimulus methods of electric, magnetic, and ultrasound stimulation and their...
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Electrochemical Biosensors for Metabolites Detection
Metabolites, including intermediate and final products in metabolic pathways, play a crucial role in physiology activities. The detection of...
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The role of thioredoxin system in the maintenance of redox homeostasis in Mycobacterium tuberculosis
Maintenance of intracellular redox homeostasis is pivotal for the survival of an organism. During intricate host–pathogen interactions, pathogens...
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Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT
Skin wounds are common in accidental injuries, and the intricacies of wound repair are closely linked to endogenous electric fields. Electrical...
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Bile Acids as Metabolic Inducers of Hepatocyte Proliferation and Liver Regeneration
PurposeLiver regeneration is an orchestrated process that mainly comprises of the proliferation of the major liver cell types, that is, the...
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Controlling liquid–liquid phase behaviour with an active fluid
Demixing binary liquids is a ubiquitous transition explained using a well-established thermodynamic formalism that requires the equality of intensive...
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Multifunctional nanocomposites DDMplusAF inhibit the proliferation and enhance the radiotherapy of breast cancer cells via modulating tumor-promoting factors and metabolic reprogramming
BackgroundTumor-promoting factors (TPF) and metabolic reprogramming are hallmarks of cancer cell growth. This study is designed to combine the newly...
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Biosensors in Point-of-Care: Molecular Analysis, Strategies and Perspectives to Health Care
Nowadays, regardless of the place and situation, it is unmistakable that we are constantly surrounded by sensors of the most diversified types and...
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Novel pH responsive hesperidin nanoformulation exerts anticancer activity on lung adenocarcinoma cells by targeting Akt/mTOR and MEK/ERK pathways
Zinc oxide nanoparticle based drug delivery enhances bioavailability of anticancer drug to the tumor site. We developed novel biocompatible ZnO...
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Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide
BackgroundCoronary artery disease is a cardiovascular disease with a high mortality and mortality rate in modern society. Vascular stent insertion to...
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Bionanocomposites for In Situ Drug Delivery in Cancer Therapy: Early and Late Evaluations
Cancer is an unsolved clinical problem and a challenge for the current medical science given the limitations of conventional therapies. Systemic...
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Metabolic Toxicity and Alteration of Cellular Bioenergetics by Hexavalent Chromium
Extensive industrialization, exhaustive mining, and whirlwind urbanization disseminate deep impact upon the world’s living being since dawn of the...
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Biocompatibility Testing
The insertion of a foreign material into the body induces a cascade of events, basically at the interface between the implanted material and the...
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Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy
Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of tumor immunotherapies such as immune checkpoint blockers,...
