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Biosensors in Point-of-Care: Molecular Analysis, Strategies and Perspectives to Health Care

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Advances in Bioelectrochemistry Volume 3

Abstract

Nowadays, regardless of the place and situation, it is unmistakable that we are constantly surrounded by sensors of the most diversified types and characteristics. With the advancements of health science, there is an increasing and intense demand for sensors applied to health care to monitor, as frequently as possible, biomarkers of interest, whether in a hospital environment, in a domestic/bedside setting or even with the comfort and elegance of high-tech wearable devices. In the biosensing field, point-of-care (PoC) analyses are becoming progressively appealing in contrast to traditional routes of laboratory assays, and the advancement of nanotechnology with syntheses, characterisations and methods of micro/nanofabrication strongly boosted research in this area during the past two decades. This chapter aims to outline the progress of (nano)materials and biomolecules in PoC sensors, as well as offering readers a concise summary of some of the numerous production methods and processes to devices manufacture, where a few selected works will be discussed, among a lengthy catalogue of excellent and successful ones, in terms of their devices’ operational/building strategies. Undoubtedly, the historical evolution of the biosensing field is of utter importance, depicting a road of apprenticeship, and we offer readers a discussed compilation of some temporal milestones from the last decades, from the emergence of the first electrochemical biosensors to the contemporary pressure to incorporating (bio)sensing platforms to smartphones and wearable devices, ubiquitous in modern life. In the light of frontier science, we assess perspectives to the future of PoC biosensing for this decade, where some directions are conspicuous, notably by the foreseeable pathway of technological advances, with accessible and more powerful apparatuses and high-tech gadgets in an environment with the Internet of things (IoT) promoting integration, miniaturisation, dense electronic embedding, automation, real-time data acquisition, digital interconnection and cloud-linked information.

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Acknowledgements

RNPC is grateful to FAPESP (process 2021/05665-7) for the funding.

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  1. Instituto de Química de São Carlos, Universidade de São Paulo, São Paulo, Brazil

    Rafael N. P. Colombo

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  1. Rafael N. P. Colombo
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Correspondence to Rafael N. P. Colombo .

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  1. Av. Trabalhador São-Carlense 400, University of Sao Paulo, São Carlos, São Paulo, Brazil

    Frank Nelson Crespilho

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Colombo, R.N.P. (2022). Biosensors in Point-of-Care: Molecular Analysis, Strategies and Perspectives to Health Care. In: Crespilho, F.N. (eds) Advances in Bioelectrochemistry Volume 3. Springer, Cham. https://doi.org/10.1007/978-3-030-97921-8_7

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