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Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin
There continues to be a need for cancer-specific ligands that can deliver a wide variety of therapeutic cargos. Ligands demonstrating both...
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Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration
Using a partial hippocampal cholinergic denervation model, we assessed the effects of the RGTA ® named OTR4132, a synthetic heparan-mimetic biopolymer...
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Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties encountered in their...
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The Role of the Brain in the Regulation of Peripheral Organs–Noradrenaline Sources in Neonatal Rats: Noradrenaline Synthesis Enzyme Activity
AbstractThis work is aimed at studying the mechanisms of reciprocal humoral regulation of noradrenaline-producing organs in rats in the perinatal...
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The Updated Review on Plant Peptides and Their Applications in Human Health
Biologically active plant peptides, consisting of secondary metabolites, are compounds (amino acids) utilized by plants in their defense arsenal....
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In vitro and in vivo anti-tumor effect of Trichobakin fused with urokinase-type plasminogen activator ATF-TBK
BackgroundTrichobakin (TBK), a member of type I ribosome-inactivating proteins (RIPs), was first successfully cloned from Trichosanthes sp Bac Kan...
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Neural stem/progenitor cell therapy for Alzheimer disease in preclinical rodent models: a systematic review and meta-analysis
BackgroundAlzheimer’s disease (AD) is a common progressive neurodegenerative disease characterized by memory impairments, and there is no effective...
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Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats
Pain contains both sensory and affective dimensions. We identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain)...
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DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy
Intrinsically disordered proteins (IDPs) are comprised of significant numbers of residues that form neither helix, sheet, nor any other canonical...
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The metabolic and functional roles of sensory nerves in adipose tissues
Homeostatic regulation of adipose tissue is critical for the maintenance of energy balance and whole-body metabolism. The peripheral nervous system...
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Heat Shock Proteins on Tumor Cell Surface as Target for Anti-Tumor Therapy (A Review)
AbstractAccording to WHO, cancer is the cause of ~5 million deaths annually. To date, there is no universal solution to fight cancer despite...
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Development of Oral Prophylactic and Therapeutic Vaccines Against HPV on the Basis of Plant Expression System
The expansion of papillomaviruses led to cancer and other related dangerous diseases in the world, prompting the development of new approaches to...
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HER-3 surface expression increases in advanced colorectal cancer representing a potential therapeutic target
HER-3 (also known as ErbB-3) is a human epidermal growth factor receptor tyrosine kinases family member, and its expression in CRC (colorectal...
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Modeling antibody drug conjugate potential using a granzyme B antibody fusion protein
BackgroundAntibody drug conjugates (ADCs) constitute a promising class of targeted anti-tumor therapeutics that harness the selectivity of monoclonal...
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Plant-derived ribosome-inactivating proteins involved in defense against plant viruses
Plant viruses are the most serious pathogens causing severe damage to crops worldwide. A variety of conventional strategies are currently being...
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Basic Fibroblast Growth Factor Induces Cholinergic Differentiation of Tonsil-Derived Mesenchymal Stem Cells
Background:Mesenchymal stem cells (MSCs) are considered a potential tool for regenerating damaged tissues due to their great multipotency into...
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Genetic modification of crop plants with ribosome-inactivating protein genes for enhanced resistance to pathogens and pests
Genetic engineering has emerged as an attractive strategy for incorporating resistance in plants against diverse pathogens and has been largely...
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Application of therapeutic protein-based fusion toxins
Purpose of reviewProtein-based therapeutics have been applied for decades to remove most malignant tumors. Many anti-tumor drugs using antibodies...
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UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation
The precise regulation of STING homeostasis is essential for its antiviral function. Post-translational modification, especially ubiquitination, is...
