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Full-length 16S rRNA gene sequencing by PacBio improves taxonomic resolution in human microbiome samples
BackgroundSequencing variable regions of the 16S rRNA gene (≃300 bp) with Illumina technology is commonly used to study the composition of human...
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Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15
Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper function. The m 4 C methyltransferase METTL15 maintains...
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High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ
Bacteria often function as a community, called the microbiota, consisting of many different bacterial species. The accurate identification of...
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VapC toxin switches M. smegmatis cells into dormancy through 23S rRNA cleavage
Mycobacterium tuberculosis is an extremely successful pathogen known for its ability to cause latent infection. The latter is connected with the...
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Gut Microbiota in Children with Hand Foot and Mouth Disease on 16S rRNA Gene Sequencing
Hand foot and mouth disease (HFMD) is a contagious and seasonal viral disease in children. The gut microbiota of HFMD children is not clear now. The...
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Evaluation of Full-Length Versus V4-Region 16S rRNA Sequencing for Phylogenetic Analysis of Mouse Intestinal Microbiota After a Dietary Intervention
The composition of microbial communities is commonly determined by sequence analyses of one of the variable (V) regions in the bacterial 16S rRNA...
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Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data
16S ribosomal RNA-based analysis is the established standard for elucidating the composition of microbial communities. While short-read 16S rRNA...
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Characterization of the mitochondrial Huso huso genome and new aspects of its organization in the presence of tandem repeats in 12S rRNA
BackgroundThe sturgeon group has been economically significant worldwide due to caviar production. Sturgeons consist of 27 species in the world....
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Analysis of the bacterial and fungal populations in South African sorghum beer (umqombothi) using full-length 16S rRNA amplicon sequencing
There is a need to profile microorganisms which exist pre-and-post-production of umqombothi , to understand its microbial diversity and the...
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18S rRNA variability maps reveal three highly divergent, conserved motifs within Rotifera
Background18S rRNA is a major component of the small subunit of the eukaryotic ribosome and an important phylogenetic marker for many groups, often...
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Single-molecule targeted accessibility and methylation sequencing of centromeres, telomeres and rDNAs in Arabidopsis
The short read-length of next-generation sequencing makes it challenging to characterize highly repetitive regions (HRRs) such as centromeres,...
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Chemical Links Between Redox Conditions and Estimated Community Proteomes from 16S rRNA and Reference Protein Sequences
Environmental influences on community structure are often assessed through multivariate analyses in order to relate microbial abundances to...
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ddPCR allows 16S rRNA gene amplicon sequencing of very small DNA amounts from low-biomass samples
BackgroundOne limiting factor of short amplicon 16S rRNA gene sequencing approaches is the use of low DNA amounts in the amplicon generation step....
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White and green striate leaves 1, predicted to encode a 16S rRNA processing protein, plays a critical role in the processing of chloroplast ribosomes in maize (Zea mays L.)
Ribosomes play a crucial role in protein biosynthesis and are linked to plant growth and development. The RimM protein has been shown to be involved...
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Conserved ribosomal RNA modification and their putative roles in ribosome biogenesis and translation
rRNA maturation requires extensive covalent modifications of riboses and bases. These modifications concern exclusively the most conserved regions of...
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rRNA Methylation and Antibiotic Resistance
AbstractMethylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for...
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Modulation of DNA/RNA Methylation by Small-Molecule Modulators and Their Implications in Cancer
Chromatin is an organized complex of DNA, histone proteins, and RNA. Chromatin modifications include DNA methylation, RNA methylation, and histone...
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Rabbit microbiota across the whole body revealed by 16S rRNA gene amplicon sequencing
BackgroundRabbit can produce meat, fur and leather, and serves as an important biomedical animal model. Understanding the microbial community of...
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Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail
BackgroundThe alveolar epithelium is exposed to numerous stimuli, such as chemicals, viruses, and bacteria that cause a variety of pulmonary diseases...
