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rRNA Methylation and Antibiotic Resistance

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Abstract

Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for corresponding methyltransferases have been found in producer strains and clinical isolates of pathogenic bacteria. In some cases, rRNA methylation by housekee** enzymes is, on the contrary, required for the action of antibiotics. The effects of rRNA modifications associated with antibiotic efficacy may be cooperative or mutually exclusive. Evolutionary relationships between the systems of rRNA modification by housekee** enzymes and antibiotic resistance-related methyltransferases are of particular interest. In this review, we discuss the above topics in detail.

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Abbreviations

DC:

decoding center

PET:

peptide exit tunnel

PTC:

peptidyl transferase center

rRNA:

ribosomal RNA

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Funding

This work was financially supported by the Russian Foundation for Basic Research (project nos. 20-04-00736 and 20-54-53014).

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Authors and Affiliations

  1. Center of Life Sciences, Skolkovo Institute of Science and Technology, 143028, Skolkovo, Russia

    I. A. Osterman, O. A. Dontsova & P. V. Sergiev

  2. Faculty of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia

    I. A. Osterman, O. A. Dontsova & P. V. Sergiev

  3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    O. A. Dontsova

  4. Institute of Functional Genomics, Lomonosov Moscow State University, 119991, Moscow, Russia

    P. V. Sergiev

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  1. I. A. Osterman
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  2. O. A. Dontsova
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Correspondence to P. V. Sergiev.

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Osterman, I.A., Dontsova, O.A. & Sergiev, P.V. rRNA Methylation and Antibiotic Resistance. Biochemistry Moscow 85, 1335–1349 (2020). https://doi.org/10.1134/S000629792011005X

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  • DOI: https://doi.org/10.1134/S000629792011005X

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