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Metastasis Models: Thermodynamics and Complexity
The thermodynamic formalism of nonequilibrium systems together with the theory of complex systems and systems biology offer an appropriate...
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Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches
BackgroundProstate cancer (PCa) is the second leading cause of tumor-related mortality in men. Metastasis from advanced tumors is the primary cause...
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Tight Junctions, Epithelial-Mesenchymal Transition, and Cancer Metastasis
Epithelial-mesenchymal transition (EMT) induces dynamic changes in the cellular organization leading to functional changes in cell migration,...
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Role of T cells in liver metastasis
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as...
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Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis
Pancreatic ductal adenocarcinoma is a highly metastatic disease and macrophages support liver metastases. Efferocytosis, or engulfment of apoptotic...
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Lipids as mediators of cancer progression and metastasis
Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this...
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Advances in lymphatic metastasis of non-small cell lung cancer
Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis and treatment technology,...
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Critical functions of extracellular matrix in brain metastasis seeding
Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both...
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Understanding and leveraging phenotypic plasticity during metastasis formation
Cancer metastasis is the process of detrimental systemic spread and the primary cause of cancer-related fatalities. Successful metastasis formation...
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METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
BackgroundDNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian cells and its nuclear role remains elusive.
ResultsHere we show that...
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ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer
Tumor metastasis severely limits the prognosis of gastric cancer patients. RNA-binding proteins (RBPs) are crucial in tumor metastasis, yet there is...
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Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of gene expression and...
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Key processes in tumor metastasis and therapeutic strategies with nanocarriers: a review
Cancer metastasis is the leading cause of cancer-related death. Metastasis occurs at all stages of tumor development, with unexplored changes...
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PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer
Overcoming distant metastasis stands as a paramount challenge in enhancing the outcomes of breast cancer treatments. Thus, delving deeper into...
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MBD2 facilitates tumor metastasis by mitigating DDB2 expression
Despite past extensive studies, the pathoetiologies underlying tumor metastasis remain poorly understood, which renders its treatment largely...
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Emerging roles of ferroptosis-related miRNAs in tumor metastasis
Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has been extensively explored during malignant tumors...
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Adhesion, metastasis, and inhibition of cancer cells: a comprehensive review
This comprehensive review delves into cancer’s complexity, focusing on adhesion, metastasis, and inhibition. It explores the pivotal role of these...
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Vascular mimicry as a facilitator of melanoma brain metastasis
Melanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of...
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SHMT2 promotes papillary thyroid cancer metastasis through epigenetic activation of AKT signaling
Cancer cells alter their metabolism and epigenetics to support cancer progression. However, very few modulators connecting metabolism and epigenetics...
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Targeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib
Osteosarcoma (OS) therapy presents numerous challenges, due largely to a low survival rate following metastasis onset. Nerve growth factor (NGF) has...
