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Key processes in tumor metastasis and therapeutic strategies with nanocarriers: a review

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Abstract

Cancer metastasis is the leading cause of cancer-related death. Metastasis occurs at all stages of tumor development, with unexplored changes occurring at the primary site and distant colonization sites. The growing understanding of the metastatic process of tumor cells has contributed to the emergence of better treatment options and strategies. This review summarizes a range of features related to tumor cell metastasis and nanobased drug delivery systems for inhibiting tumor metastasis. The mechanisms of tumor metastasis in the ideal order of metastatic progression were summarized. We focus on the prominent role of nanocarriers in the treatment of tumor metastasis, summarizing the latest applications of nanocarriers in combination with drugs to target important components and processes of tumor metastasis and providing ideas for more effective nanodrug delivery systems.

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No datasets have been generated in this review, so no data availability statement is included.

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Acknowledgements

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Funding

This work was supported by the Natural Science Foundation of Shandong Province (ZR2023MC122) and the Open Projects Fund of NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine (2021QRECM03).

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Authors and Affiliations

  1. School of Clinical Medicine, Weifang Medical University, 261053, Weifang, China

    Hongjie Li

  2. School of Bioscience and Technology, Weifang Medical University, 261053, Weifang, China

    Haiqin Huang, Qitao Jia, Qingdong Zhang & **gkun Bai

  3. National Glycoengineering Research Center, Shandong University, 250012, **an, China

    Haining Tan

  4. Department of Pediatric Respiratory and Critical Care, Qilu Hospital of Shandong University Dezhou Hospital, 253000, Dezhou, China

    Weina Song

  5. School of Pharmacy, Weifang Medical University, 261053, Weifang, China

    Baolong Zhou

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  1. Hongjie Li
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  2. Haiqin Huang
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  3. Haining Tan
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  4. Qitao Jia
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  5. Weina Song
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  6. Qingdong Zhang
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  7. Baolong Zhou
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  8. **gkun Bai
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Contributions

HL: Methodology, software, writing—original draft. HH, HT, QJ and WS: Methodology, literature screening. QZ and BZ: Funding acquisition, supervision. JB: Conceptualization, writing—review & editing. All authors reviewed the manuscript.

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Correspondence to Qingdong Zhang, Baolong Zhou or **gkun Bai.

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Li, H., Huang, H., Tan, H. et al. Key processes in tumor metastasis and therapeutic strategies with nanocarriers: a review. Mol Biol Rep 51, 197 (2024). https://doi.org/10.1007/s11033-023-08910-7

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