Search
Search Results
-
Homology Modeling Methods and Protocols
This detailed volume provides state-of-the-art methodologies and reviews of important topics in the field of homology modeling. From homology...
-
Homology Modeling of Transporter Proteins
Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological...
-
Protein Homology Modeling for Effective Drug Design
The effective drug design, especially for combating the multi-drug-resistant bacterial pathogens, requires more and more sophisticated procedures to...
-
Specificities of Modeling of Membrane Proteins Using Multi-Template Homology Modeling
Structures of membrane proteins are challenging to determine experimentally and currently represent only about 2% of the structures in the Protein...
-
Homology Modeling of the G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) are therapeutically important family of membrane proteins. Despite growing number of experimental structures...
-
Contact-Assisted Threading in Low-Homology Protein Modeling
The ability to successfully predict the three-dimensional structure of a protein from its amino acid sequence has made considerable progress in the...
-
Homology Modeling of Antibody Variable Regions: Methods and Applications
Adaptive immunity specifically protects us from antigenic challenges. Antibodies are key effector proteins of adaptive immunity, and they are...
-
Homology Modeling in the Twilight Zone: Improved Accuracy by Sequence Space Analysis
The analysis of the relationship between sequence and structure similarities during the evolution of a protein family has revealed a limit of...
-
Specificities of Protein Homology Modeling for Allosteric Drug Design
The allosteric binding sites are usually located in the flexible areas of proteins, which are hardly visible in the crystal structures. However,...
-
Homology modeling of Forkhead box protein C2: identification of potential inhibitors using ligand and structure-based virtual screening
Overexpression of Forkhead box protein C2 (FOXC2) has been associated with different types of carcinomas. FOXC2 plays an important role in the...
-
Homology modeling and virtual characterization of cytochrome c nitrite reductase (NrfA) in three model bacteria responsible for short-circuit pathway, DNRA in the terrestrial nitrogen cycle
NrfA is the molecular marker for dissimilatory nitrate reduction to ammonium (DNRA) activity, catalysing cytochrome c nitrite reductase enzyme....
-
Persistent Homology for RNA Data Analysis
Molecular representations are of great importance for machine learning models in RNA data analysis. Essentially, efficient molecular descriptors or...
-
Modeling of Protein Complexes
The recent advances in structural biology, combined with continuously increasing computational capabilities and development of advanced softwares,...
-
The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model
The TOPK enzyme (also known as PBK) is a serine-threonine protein kinase that is rarely detected in normal tissues yet is found to be overexpressed...
-
Functionality of the Na+-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii inferred from homology modeling
Members of the family Prevotellaceae are Gram-negative, obligate anaerobic bacteria found in animal and human microbiota. In Prevotella bryantii , the...
-
Functional Annotation from Structural Homology
With the nexus of super computing and the biotech revolution, it seems an era of predictive biology through systems biology may be at hand. Modern...
-
Omics and Remote Homology Integration to Decipher Protein Functionality
In the recent years, several “omics” technologies based on specific biomolecules (from DNA, RNA, proteins, or metabolites) have won growing...
-
Modeling of Olfactory Receptors
Olfactory receptors (ORs) form the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is...
-
Exploring novel natural compound inhibitors for Parkinsonian receptor (DJ1) by homology modeling, molecular docking and MD simulations
The present study has been done with the aim of applying computational tools for the analysis of bioactive constituents that are active against...
-
Homology Modeling Using GPCRM Web Service
Homology modeling methods are commonly used for quick and precise construction of a desired protein or its mutant using protein templates, which were...