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HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1/SLC3A2 pathway
BackgroundIn patients with acute aortic dissection (AAD), increased vascular smooth muscle cell (VSMC) apoptosis has been found. Human...
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Long range PCR-based deep sequencing for haplotype determination in mixed HCMV infections
BackgroundShort read sequencing has been used extensively to decipher the genome diversity of human cytomegalovirus (HCMV) strains, but falls short...
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Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the...
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Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells
Human cytomegalovirus (HCMV) is an opportunistic pathogen causing severe diseases in immunosuppressed individuals. To replicate its double-stranded...
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Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro
Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life...
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Anti-cytomegalovirus antibody levels stratify human immune profiles across the lifespan
Human cytomegalovirus (hCMV) is a ubiquitous latent persistent herpesvirus infecting 60–90% of the population worldwide. hCMV carriage in...
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Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33
BackgroundG-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked...
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Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics
Human cytomegalovirus (HCMV) can result in either productive or non-productive infection, with the latter potentially leading to viral latency. The...
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Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
AbstractHuman cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in...
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Die Wirkungsweise des ZAP-Proteins bei Cytomegalievirus-Infektionen
The repertoire of antiviral drugs and vaccines for many viral infections is astonishingly small. No licensed vaccine against human cytomegalovirus...
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Human cytomegalovirus UL24 and UL43 products participate in SAMHD1 subcellular localization
This report has analyzed the potential role of Human Cytomegalovirus (HCMV) UL24 and UL43 products in modulating the subcellular location of a host...
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Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
A library of 18 structurally diverse semisynthetic lupane, oleanane, and ursane types triterpenoids, including C19- or C28-(1,2,3-triazolyl)- and...
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Dual inhibition of innate immunity and apoptosis by human cytomegalovirus protein UL37x1 enables efficient virus replication
Immune evasion and inhibition of apoptosis are required for successful virus infection. However, inhibition of apoptosis can increase antiviral...
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Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability
Viral infections enhance cancer risk and threaten host genome integrity. Although human cytomegalovirus (HCMV) proteins have been detected in a wide...
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Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH
Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in immunocompromised individuals including transplant...
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Metagenomic Next-Generation Sequencing Contributes to the Early Diagnosis of Mixed Infections in Central Nervous System
Central nervous system (CNS) infections represent a challenge due to the complexities associated with their diagnosis and treatment, resulting in a...
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In Vitro Amplification and Selection of Engineered RNase P Ribozyme for Gene Targeting Applications
Ribozymes engineered from the RNase P catalytic RNA (M1 RNA) represent promising gene-targeting agents for clinical applications. We describe in this...
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Pathogenesis of human cytomegalovirus in the immunocompromised host
Human cytomegalovirus (HCMV) is a herpesvirus that infects ~60% of adults in developed countries and more than 90% in develo** countries. Usually,...
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Kinases and therapeutics in pathogen mediated gastric cancer
IntroductionMany pathogens have coexisted with humans for millennia and can cause chronic inflammation which is the cause of gastritis. Gastric...
