Search
Search Results
-
Drug induced nephrotoxicity- A mechanistic approach
The main goal of the treatment of patients is its effectiveness and safety. However, all currently prescribed drugs being used also have certain...
-
Aldehyde dehydrogenase-positive melanoma stem cells in tumorigenesis, drug resistance and anti-neoplastic immunotherapy
Cancer stem cells (CSCs), a rare subset of cancer cells, are well known for their self-renewing capacity. CSCs play a critical role in therapeutic...
-
Role of Bioinformatics in Drug Design and Discovery
Bioinformatics can speed up the identification of therapeutic targets, screening drug candidates, and refinement of those candidates. It can also...
-
Application of CRISPR–Cas Technology in Drug Development
The discovery of clustered regularly interspaced short palindromic repeat (CRISPR)-Cas technology has transformed the science of genome editing,...
-
Role of Fra-2 in cancer
Fos-related antigen-2 (Fra-2) is the most recently discovered member of the Fos family and, by dimerizing with Jun proteins, forms the activator...
-
Nanoscale Smart Drug Delivery Systems and Techniques of Drug Loading to Nanoarchitectures
Conventional drug delivery systems suffer from less therapeutic efficiency with adverse side effects and poor specificity in action. The progression...
-
Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives
Epithelial ovarian cancer (EOC) is a complex disease with diverse histological subtypes, which, based on the aggressiveness and course of disease...
-
Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus
The advancement in pharmaceutical research has led to the discovery and development of new combinatorial life-saving drugs. Rapamycin is a macrolide...
-
Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment
Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a...
-
Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine
In recent years, the rapid emergence of 3D organoid technology has garnered significant attention from researchers. These miniature models accurately...
-
Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors
Meningioma is the most common central nervous system (CNS) tumor. In recent decades, several efforts have been made to eradicate this disease....
-
A novel approach to predicting the synergy of anti-cancer drug combinations using document-based feature extraction
BackgroundTo reduce drug side effects and enhance their therapeutic effect compared with single drugs, drug combination research, combining two or...
-
Production and characterization of a camelid single domain anti-CD22 antibody conjugated to DM1
Antibody drug conjugates (ADCs) with twelve FDA approved drugs, known as a novel category of anti-neoplastic treatment created to merge the...
-
The Causal Relationship between PCSK9 Inhibitors and Osteoporosis Based on Drug-Targeted Mendelian Combined Mediation Analysis
PCSK9 inhibitors have been shown to lower serum low density lipoprotein cholesterol (LDL - C) levels and are considered integral in the treatment of...
-
Involvement and targeted intervention of benzo(a)pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma
During the development of hepatocellular carcinoma (HCC), the mutual adaptation and interaction of HCC cells and the microenvironment play an...
-
A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
BackgroundDespite recent advances in drug discovery, cancer is still one of the most lethal health problems worldwide. In most cases, standard...
-
Aquaporins in colorectal cancer: exploring their role in tumorigenesis, metastasis, and drug response
Aquaporins (AQPs) are small, integral proteins facilitating water transport across plasma cell membranes in response to osmotic gradients. This...
-
The role of epigenetic modifications in drug resistance and treatment of breast cancer
BackgroundBreast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is...
-
Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
Autophagy is a biological process that maintains cellular homeostasis and regulates the internal cellular environment. Hyperactivating autophagy to...
-
Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells
Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer relapse. This resistance mostly originates from rare, but...
