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Role of Sam68 as an adaptor protein in inflammatory signaling
Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulating multiple steps of RNA...
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3...
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A lightweight classification of adaptor proteins using transformer networks
BackgroundAdaptor proteins play a key role in intercellular signal transduction, and dysfunctional adaptor proteins result in diseases. Understanding...
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The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
p97, also known as valosin-containing protein, is an essential cytosolic AAA+ (ATPases associated with diverse cellular activities) hexamer that...
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Post-bisulfite Adaptor Tagging Based on an ssDNA Ligation Technique (tPBAT)
Post-bisulfite adaptor tagging (PBAT) is a concept that enables the preparation of an efficient sequencing library from bisulfite-treated DNA, and it...
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Post-bisulfite Adaptor Tagging with a Highly Efficient Single-Stranded DNA Ligation Technique
Post-bisulfite adaptor tagging (PBAT) is a procedure for efficiently preparing a sequencing library for whole-genome bisulfite sequencing (WGBS). The...
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AAA+ protease-adaptor structures reveal altered conformations and ring specialization
ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor. Here we present high-resolution cryo-EM structures of Escheric...
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Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells
Disabled 2 (Dab2), an adaptor protein, is up regulated in the hair follicle stem cells (HFSCs); however, its role in any tissue stem cells has not...
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Adaptor protein HIP-55-mediated signalosome protects against ferroptosis in myocardial infarction
Ischemic heart disease is a leading cause of death worldwide. Myocardial infarction (MI) results in cardiac damage due to cell death and insufficient...
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Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
BackgroundC3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF...
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FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis
BackgroundCholesterol plays a vital role in multiple physiological processes. Cellular uptake of cholesterol is mediated primarily through...
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The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish
BackgroundLymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the development of the venous vasculature, both at the cellular...
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Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization
Clathrin-mediated endocytosis (CME) is the main route of internalization from the plasma membrane. It is known that the heterotetrameric AP2 clathrin...
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Adaptor protein complex interaction map in Arabidopsis identifies P34 as a common stability regulator
Adaptor protein (AP) complexes are evolutionarily conserved vesicle transport regulators that recruit coat proteins, membrane cargoes and coated...
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Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants
Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl...
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USP13 modulates the stability of the APC/C adaptor CDH1
BackgroundThe cell division cycle is a process that is exquisitely controlled by a complex interplay between E3 ubiquitin ligases and...
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In silico analysis of the possible crosstalk between O-linked β-GlcNAcylation and phosphorylation sites of Disabled 1 adaptor protein in vertebrates
Disabled 1 (Dab1) is an adaptor protein with essential functions regulated by reelin signaling and affects many biological processes in the nervous...
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A phase separation-fortified bi-specific adaptor for conditional tumor killing
A common approach in therapeutic protein development involves employing synthetic ligands with multivalency, enabling sophisticated control of signal...
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HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain
Hematopoietic adaptor containing SH3 and SAM domains-1 (HACS1) is a signaling protein with two juxtaposed protein–protein interaction domains and an...
