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John Squire and the myosin thick filament structure in muscle
The structure of the thin, actin-containing filament of muscle is both highly conserved across a broad range of muscle types and is now well...
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The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles
Contraction of striated muscle is regulated by a dual mechanism involving both thin, actin-containing filament and thick, myosin-containing filament....
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N-Terminal Fragment of Cardiac Myosin Binding Protein C Modulates Cooperative Mechanisms of Thin Filament Activation in Atria and Ventricles
AbstractCardiac myosin binding protein C (cMyBP-C) is one of the essential control components of the myosin cross-bridge cycle. The C-terminal part...
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Purification and CryoEM Image Analysis of the Bacterial Flagellar Filament
The bacterial flagellum is a large assembly of about 30 different proteins and is divided into three parts: the filament that acts as a screw...
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Unique Role of Vimentin in the Intermediate Filament Proteins Family
AbstractIntermediate filaments (IFs), being traditionally the least studied component of the cytoskeleton, have begun to receive more attention in...
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Self-assembly of smooth muscle myosin filaments: adaptation of filament length by telokin and Mg·ATP
The contractile apparatus of smooth muscle is malleable to accommodate stress and strain exerted on the muscle cell and to maintain optimal...
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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize...
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Molecular insights into titin’s A-band
The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that...
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Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks
Coordinated polymerization of actin filaments provides force for cell migration, morphogenesis and endocytosis. Cap** protein (CP) is a central...
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Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments
Myosin binding protein C (MyBP-C) is an accessory protein of the thick filament in vertebrate cardiac muscle arranged over 9 stripes of intervals of...
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Mechanism of post-tetanic depression of slow muscle fibres
A brief tetanic stimulation has a very different effect on the subsequent isometric twitch force of fast and slow skeletal muscles. Fast muscle...
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Chloroplast-actin filaments decide the direction of chloroplast avoidance movement under strong light in Arabidopsis thaliana
Chloroplast-actin (cp-actin) filaments are crucial for light-induced chloroplast movement, and appear in the front region of moving chloroplasts when...
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The vertebrate muscle superlattice: discovery, consequences, and link to geometric frustration
Early x-ray diffraction studies of muscle revealed spacings larger than the basic thick filament lattice spacing and led to a number of speculations...
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Force and kinetics of fast and slow muscle myosin determined with a synthetic sarcomere–like nanomachine
Myosin II is the muscle molecular motor that works in two bipolar arrays in each thick filament of the striated (skeletal and cardiac) muscle,...
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Recessive TMOD1 mutation causes childhood cardiomyopathy
Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic...
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Live-Cell Imaging of the Assembly and Ejection Processes of the Bacterial Flagella by Fluorescence Microscopy
Bacterial flagella are molecular machines used for motility and chemotaxis. The flagellum consists of a thin extracellular helical filament as a...
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Design Principles and Benefits of Spatially Explicit Models of Myofilament Function
Spatially explicit models of muscle contraction include fine-scale details about the spatial, kinetic, and/or mechanical properties of the biological...
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The 50th anniversary of the European Society for Muscle Research: a journey through half a century of scientific advances
The European Society for Muscle Research (ESMR) started in 1971 as “European Muscle Club” in a joint initiative of Marcus Schaub, Eduard Jenny and...
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Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio
Actin, tropomyosin and troponin, the proteins that comprise the contractile apparatus of the cardiac thin filament, are highly conserved across...
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LUZP1 regulates the maturation of contractile actomyosin bundles
Contractile actomyosin bundles play crucial roles in various physiological processes, including cell migration, morphogenesis, and muscle...
