Search
Search Results
-
Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in...
-
Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data
AbstractSome tricyclic antidepressants (TCAs), including amitriptyline (ATL), clomipramine (CLO), and desipramine (DES), are known to be effective...
-
Molecular Mechanism of the Circadian Clock
Nearly all organisms possess a circadian clock, a genetically determined device that generates endogenous oscillations with a period of approximately...
-
Fusarium wilt in banana: unraveling molecular aspects of host–pathogen interaction and resistance mechanism
Bananas and plantains (Musa spp.) are an important socio-economic fruit crop grown worldwide. Their production across the regions where they are...
-
Molecular Mechanism of Plant–Bacteria Interactions
Over the past few decades, significant progress has been made in understanding the impact of microbes on plant cellular functions and how plants...
-
Network pharmacology, molecular docking, and molecular dynamics simulation analysis reveal the molecular mechanism of halociline against gastric cancer
Halociline, a derivative of alkaloids, was isolated from the marine fungus Penicillium griseofulvum by our group. This remarkable compound exhibits...
-
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction between them has been a...
-
Molecular Mechanism of Yangshen Maidong Decoction in the Treatment of Chronic Heart Failure based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations
Chronic heart failure (CHF) is a complex multifactorial clinical syndrome leading to abnormal cardiac structure and function. The severe form of this...
-
The Prothrombin-Prothrombinase Interaction
The hemostatic response to vascular injury entails a sequence of proteolytic events where several inactive zymogens of the trypsin family are...
-
Exploring the molecular mechanism of Epimedium for the treatment of ankylosing spondylitis based on network pharmacology, molecular docking, and molecular dynamics simulations
Ankylosing spondylitis (AS) is a rheumatic disease that causes inflammation and bone formation in the spine. Despite significant advances in...
-
Early molecular events in the interaction between Magnaporthe oryzae and rice
Rice is a staple crop feeding more than 50% of the world’s population and, its sustainable production is crucial to the global food security....
-
Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection
Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial tetrameric protein complex. Although inorganic phosphate (Pi) is...
-
Interaction of Glycated Albumin with Receptor for Glycation End Products According to Molecular Modeling Data
AbstractIn diabetes mellitus (DM) patients, the accumulation of advanced glycation end products (AGE) leads to inflammation and oxidative stress...
-
Molecular Toxicity Mechanism of Microplastics in the Reservoir
Recently, the toxicity of microplastics (MPs) has attracted global public health concerns. In this chapter, we reviewed the published studies on MPs...
-
Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular docking
Purpose: Zhizi-Bopi decoction (ZZBPD) is a classic herbal formula with wide clinical applications in treating liver diseases including hepatitis B....
-
Exploration of the molecular mechanism of tea polyphenols against pulmonary hypertension by integrative approach of network pharmacology, molecular docking, and experimental verification
Pulmonary hypertension, a common complication of chronic obstructive pulmonary disease, is a major global health concern. Green tea is a popular...
-
Uncovering the potential molecular mechanism of liraglutide to alleviate the effects of high glucose on myoblasts based on high-throughput transcriptome sequencing technique
BackgroundMyoblasts play an important role in muscle growth and repair, but the high glucose environment severely affects their function. The purpose...
-
Network pharmacology, molecular docking, and molecular dynamics simulation to elucidate the mechanism of anti-aging action of Tinospora cordifolia
Scientific research has demonstrated that Tinospora cordifolia acts as an anti-aging agent in several experimental models, generating global interest...
-
Proteomics of Plant-Nanoparticle Interaction Mechanism
Plants are continuously exposed to a broad array of hostile environmental conditions that confine plant growth and restrict the yield of crop plants....
-
Mechanism unravelling the effect of 1-Methylcyclopropene (1-MCP) through molecular docking approach and postharvest analysis in papaya
1-Methylcyclopropene (1-MCP), an ethylene receptor inhibitor, has been widely applied in delaying the ripening of fruits including several tropical...
