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Swarna Bhasma Induces Antigen-Presenting Abilities of Macrophages and Helps Antigen Experienced CD4+ T Cells to Acquire Th1 Phenotypes Against Leishmania donovani Antigens
In leishmaniasis, the protective immunity is largely mediated by proinflammatory cytokine producing abilities of T cells and an efficient parasite...
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Presence of anti-Leishmania infantum antibodies in sheep (Ovis aries) in Spain
Sandflies are the primary transmission vector for Leishmania spp parasite in endemic regions. The role of other animals, different from the dog, is...
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The Therapeutic Effects of Curcumin-coated Gold Nanoparticle Against Leishmania Major Causative Agent of Zoonotic Cutaneous Leishmaniasis (ZCL): An In Vitro and In Vivo Study
We synthesized and characterized curcumin-coated gold nanoparticles (Cur@AuNPs) and investigated their stability, cytotoxicity, leishmanicidal...
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Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
BackgroundCharacterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights into...
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Engineering a multi-epitope vaccine candidate against Leishmania infantum using comprehensive Immunoinformatics methods
Visceral leishmaniasis (VL) is a severe disease with particular endemicity in over 80 countries worldwide. There is no approved human vaccine against...
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A compared histopathological study on kidneys and eye bulbs in distinct clinical presentations of canine leishmaniasis by Leishmania infantum
Canine leishmaniasis (CanL) caused by Leishmania infantum commonly progresses with renal and ophthalmic lesions associated with active systemic...
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Is leishmaniasis the new emerging zoonosis in the world?
Leishmania is a genus of parasitic protozoa that causes a disease called leishmaniasis. Leishmaniasis is transmitted to humans through the bites of...
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Development of a chimeric protein based on a proteomic approach for the serological diagnosis of human tegumentary leishmaniasis
Leishmania braziliensis is responsible for most cases of human tegumentary leishmaniasis (HTL) and has caused a wide range of clinical...
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Assessment of circulating immune complexes in canine leishmaniosis and dirofilariosis
Canine leishmaniosis (CanL) by Leishmania infantum ( L.i .) and heartworm disease by Dirofilaria immitis ( D.i. ) are common zoonotic vector-borne...
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Efferocytosis: a double-edged sword in microbial immunity
Efferocytosis is characterized as the rapid and efficient process by which dying or dead cells are removed. This type of clearance is initiated via...
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Immunoinformatics Approach to Design a Novel Subunit Vaccine Against Visceral Leishmaniasis
Visceral leishmaniasis (VL) infection is mostly caused by Leishmania donovani and affects countries worldwide. Despite the need for a safe and...
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Development of an immunogen containing CD4+/CD8+ T-cell epitopes for the prophylaxis of tegumentary leishmaniasis
AbstractTegumentary leishmaniasis (TL) is a disease of high severity and incidence in Brazil, and Leishmania braziliensis is its main etiological...
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Origin, Phenotype, and Function of Mouse Dendritic Cell Subsets
Dendritic cells are cells of hematopoietic origin that are specialized in antigen presentation and instruction of innate and adaptive immune... -
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Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients
A large proportion of HIV-coinfected visceral leishmaniasis (VL-HIV) patients exhibit chronic disease with frequent VL recurrence. However, knowledge...
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Harnessing Bioinformatic Approaches to Design Novel Multi-epitope Subunit Vaccine Against Leishmania infantum
Kala-azar or visceral leishmaniasis (VL) is the most important vector-borne protozoan disease and a life-threatening problem in the globe due to the...
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DC-SIGNs
Among the PRRs, the DC-SIGN (CD209) directly involves in diverse molecular events in the interaction of DCs with some pathogens. DC-SIGN as a TM... -
Galectins
Immune response is regulated by multiple pathways with activation and tolerance of immune cells. Galectins are one of the most ancient mammalian... -
Non-ABO Blood Group Systems
After the ABO blood group discovery, Karl Landsteiner and his colleagues further discovered additional markers of blood groups of MN and P, and a...