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VNS improves VSMC metabolism and arteriogenesis in infarcted hearts through m/n-AChR-Akt-SDF-1α in adult male rats
Vagal nerve stimulation (VNS) provides a novel therapeutic strategy for injured hearts by activating cholinergic anti-inflammatory pathways. However,...
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Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release
Bone marrow-derived human mesenchymal stem cells (hMSCs) are recruited to damaged or inflamed tissues where they contribute to tissue repair. This...
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Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4
AimsNeointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia...
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Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet
The release of paracrine factors from endothelial progenitor cell (EPC) sheet is a central mechanism of tissue repair. The purpose of this study was...
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Conditioned medium of induced pluripotent stem cell derived neuromesodermal progenitors enhances cell migration in vitro
BackgroundIdentification of novel cell-based therapy sources has been of great interest in recent years to provide alternative and available therapy...
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Trained innate immunity modulates osteoblast and osteoclast differentiation
Macrophages are key regulators in bone repair and regeneration. Recent studies have shown that long-term epigenetic changes and metabolic shifts...
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CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2
BackgroundSome chemokine receptors referred to as atypical chemokine receptors (ACKRs) are thought to non-signaling decoys because of their inability...
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CXCR4 promotes B cell viability by the cooperation of nuclear factor (erythroid-derived 2)-like 2 and hypoxia-inducible factor-1α under hypoxic conditions
B cells that interact with T cells play a role in regulating the defense function by producing antibodies and inflammatory cytokines. C-X-C chemokine...
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Role of Hypoxia in Mesenchymal Stem Cells from Dental Pulp: Influence, Mechanism and Application
Mesenchymal stem cells (MSCs) from dental pulp (DP-MSCs), which include dental pulp stem cells (DPSCs) isolated from permanent teeth and stem cells...
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Rejuvenated endothelial progenitor cells through overexpression of cellular prion protein effectively salvaged the critical limb ischemia in rats with preexisting chronic kidney disease
BackgroundThis study tested the hypothesis that overexpression of cellular prion protein in endothelial progenitor cells (PrPc OE -EPCs), defined as...
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Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling
Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling,...
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Short-wave enhances mesenchymal stem cell recruitment in fracture healing by increasing HIF-1 in callus
BackgroundAs a type of high-frequency electrotherapy, a short-wave can promote the fracture healing process; yet, its underlying therapeutic...
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Dimethyloxalyl Glycine Regulates the HIF-1 Signaling Pathway in Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal and multidirectional differentiation capabilities. Dimethyloxalyl glycine...
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Recent advances in pre-conditioned mesenchymal stem/stromal cell (MSCs) therapy in organ failure; a comprehensive review of preclinical studies
Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and...
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A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys
BackgroundHematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the...
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Mesenchymal Stromal Cells for Wound Healing Therapy: From Expectations to Reality
This chapter addresses the therapeutic potential of mesenchymal stromal/stem cells (MSCs), focusing on those derived from bone marrow and adipose...
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Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma
Although CD19-specific chimeric antigen receptor (CAR) T cells are curative for patients with relapsed or refractory large B-cell lymphoma (R/R...
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Application of Ultrasound to Enhancing Stem Cells Associated Therapies
Pluripotent stem cell therapy exhibits self-renewal capacity and multi-directional differentiation potential and is considered an important...
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p-Smad3 differentially regulates the cytological behavior of osteoclasts before and after osteoblasts maturation
BackgroundA series of previous investigations have revealed that p-Smad3 plays a facilitative role in the differentiation and maturation of...
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Erythropoietin: Functions and Therapeutic Potential
AbstractErythropoietin (EPO) exerts its effect on erythroid cells through interaction with the EPO receptor (EPOR), the so-called “canonical...