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Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development
BackgroundCircRNAs are a class of noncoding RNAs with tissue- and development-specific expression characteristics. In many mammals, primordial...
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SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I
BackgroundOvarian folliculogenesis is a tightly regulated process leading to the formation of functional oocytes and involving successive quality...
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Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes
Previous works have shown that zearalenone (ZEA), as an estrogenic pollutant, has adverse effects on mammalian folliculogenesis. In the present...
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HDAC6 regulates primordial follicle activation through mTOR signaling pathway
Primordial follicle pool established perinatally is a non-renewable resource which determines the female fecundity in mammals. While the majority of...
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miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis
Primordial follicle pool provides all available oocytes throughout the whole reproductive life span. Abnormal regulation in primordial follicle...
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Stem Cells in Adult Mice Ovaries Form Germ Cell Nests, Undergo Meiosis, Neo-oogenesis and Follicle Assembly on Regular Basis During Estrus Cycle
Very small embryonic-like (VSELs) and ovarian (OSCs) stem cells are located in adult mammalian ovary surface epithelium (OSE). OSCs can expand...
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LSM14B controls oocyte mRNA storage and stability to ensure female fertility
Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and...
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High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein
BackgroundThe reproductive performance of chickens mainly depends on the development of follicles. Abnormal follicle development can lead to...
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Follicle inhibition at the primordial stage without increasing apoptosis, with a combination of everolimus, verapamil
The aim of the present study was to test whether inhibition of ovarian primordial follicles and subsequent activation can be achieved by transient...
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CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes
The DNA methylation is gradually acquired during oogenesis, a process sustained by successful follicle development. However, the functional roles of...
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Dysfunctional Ovarian Stem Cells Due to Neonatal Endocrine Disruption Result in PCOS and Ovarian Insufficiency in Adult Mice
Polycystic ovarian syndrome (PCOS) is a common global cause of anovulatory infertility but underlying etiology leading to PCOS still remains elusive....
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FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells
BackgroundThe maintenance of genome stability in primordial germ cells (PGCs) is crucial for the faithful transmission of genetic information and the...
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Mesenchymal stem cells promote ovarian reconstruction in mice
BackgroundStudies have shown that chemotherapy and radiotherapy can cause premature ovarian failure and loss of fertility in female cancer patients....
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Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential
Very small embryonic-like stem cells (VSELs) are a dormant population of development early stem cells deposited in adult tissues that as demonstrated...
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A chromosome-level genome assembly of Hong Kong catfish (Clarias fuscus) uncovers a sex-determining region
BackgroundHong Kong catfish ( Clarias fuscus ) is an ecologically and economically important species that is widely distributed in freshwater regions...
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The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice
BackgroundHelicase for meiosis 1 (HFM1), a putative DNA helicase expressed in germ-line cells, has been reported to be closely associated with...
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Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth
BackgroundMammalian follicle development is characterized by extensive changes in morphology, endocrine responsiveness, and function, providing the...
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Human theca arises from ovarian stroma and is comprised of three discrete subtypes
Theca cells serve multiple essential functions during the growth and maturation of ovarian follicles, providing structural, metabolic, and...
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Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis
HFM1 (helicase for meiosis 1) is widely recognized as an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. HFM1 is a candidate...
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The role of zinc in follicular development
Follicles consist of specialized somatic cells that encase a single oocyte. Follicle development is a process regulated by a variety of endocrine,...
