Search
Search Results
-
Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway
BackgroundAtherosclerosis (AS) is a persistent inflammatory condition triggered and exacerbated by several factors including lipid accumulation,...
-
Effect of Anakinra on the Gene Expression of Receptors Activated by the Peroxisome Proliferator in the Rat Brain in the Lithium Pilocarpine Model of Epilepsy
AbstractThe role of neuroinflammation in the mechanisms of epileptogenesis has been widely discussed in recent years. One of the factors...
-
Association of gene polymorphisms with body weight changes in prediabetic patients
BackgroundRecent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R ...
-
Transcriptional state dynamics lead to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma
Intra-tumor heterogeneity contributes to treatment failure and poor survival in urothelial bladder carcinoma (UBC). Analyzing transcriptome from a...
-
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus
Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein...
-
Bioinformatics analysis reveals the potential target of rosiglitazone as an antiangiogenic agent for breast cancer therapy
BackgroundSeveral studies have demonstrated the antitumor activity of rosiglitazone (RGZ) in cancer cells, including breast cancer cells. However,...
-
AgeMeta: Quantitative Gene Expression Database of Mammalian Aging
AbstractAgeMeta is a database that provides systemic and quantitative description of mammalian aging at the level of gene expression. It encompasses...
-
Effect of Cardarine on Gene Expression of Proteins Involved in Epileptogenesis in Rat Hippocampus in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy
AbstractDuring the last years, the role of astro- and microglial cells and associated neuroinflammation in the pathogenesis of epilepsy has been...
-
AdipoRon Effect on Expression of Lipid Metabolism Genes in Cultured Human Primary Macrophages
AbstractAtherosclerosis is characterized by excessive uptake of cholesterol-rich low-density lipoprotein (LDL) by vascular wall macrophages. The...
-
Single-nucleus RNA sequencing and lipidomics reveal characteristics of transcriptional and lipid composition in porcine longissimus dorsi muscle
BackgroundGlobal per capita meat consumption continues to rise, especially pork. Meat quality is influenced by the content of intramuscular fat (IMF)...
-
Differential gene expression of Wharton’s jelly-derived mesenchymal cells mediated by graphene oxide in basal and osteo-induced media
BackgroundGraphene oxide (GO) is widespread in scaffold engineering owing to its extraordinary properties such as multiple oxygen functional groups,...
-
Regulation of PPARγ/CPT-1 expression ameliorates cochlear hair cell injury by regulating cellular lipid metabolism and oxidative stress
This study aimed to investigate the protective effects of PPARγ/CPT-1 regulation on cisplatin-induced cochlear hair cell injury. The viability,...
-
The Involvement of the Gagr Gene, a Domesticated gag Retrovirus Gene, in the Stress-Response Pathway in Different Drosophila Species
AbstractThe Gagr gene is a domesticated gag retroelement gene in Drosophila melanogaster , whose function is associated with the stress response. The...
-
Functional differentiation of the ovine preadipocytes —insights from gene expression profiling
The preadipocytes differentiation is a vital process of lipogenesis; exploring the molecular mechanisms of lipogenesis contributes to improve the...
-
Association study to evaluate Foxo1 and Foxo3 gene polymorphisms in polycystic ovary syndrome: a preliminary case–control study and in silico analysis
BackgroundPolycystic ovary syndrome (PCOS) is known as a multifactorial and multi-gene-mediated endocrine disorder among women of reproductive age....
-
A review on gene regulatory network reconstruction algorithms based on single cell RNA sequencing
BackgroundUnderstanding gene regulatory networks (GRNs) is essential for unraveling the molecular mechanisms governing cellular behavior. With the...
-
Molecular evolution of transcription factors AF4/FMR2 family member (AFF) gene family and the role of lamprey AFF3 in cell proliferation
AF4/FMR2 family member (AFF) proteins are a group of transcriptional regulators that can regulate gene transcription and play an important role in...
-
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers
The limited differentiation ability of adipose-derived stem cells (ADSCs) limits their application in stem cell therapy and regenerative medicine....
-
Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway
Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Chemoresistance leads to poor responses to conventional...
-
A novel candidate gene CLN8 regulates fat deposition in avian
BackgroundThe fat deposition has a crucial role in animal meat flavor, and fat deposition-related traits are vital for breeding in the commercial...
