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Could invasive lagomorphs increase the predation risk for guanaco (Lama guanicoe) by puma (Puma concolor) in the Chilean Central Andes?
Invasive species can have complex direct and indirect impacts on ecosystems. The impacts of invasive prey species on native prey can be difficult to...
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Determining puma habitat suitability in the Eastern USA
Pumas ( Puma concolor ) were eliminated from most of the eastern USA a century ago. In the past couple of decades, their recovery in the West has...
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Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice
Transcriptional activation of target genes is essential for TP53-mediated tumour suppression, though the roles of the diverse TP53-activated target...
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Puma density, habitat use, and activity patterns across a mosaic landscape of ranches, game reserves, and a protected area in central Argentina
Human-carnivore conflict can lead to serious reduction and even extirpation of top predators when management policies are inadequate or are absent....
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MicroRNA-495 suppresses pre-eclampsia via activation of p53/PUMA axis
Linkage between microRNAs (miRNAs) and pre-eclampsia (PE) has been documented. Here, we focused on miR-495 in PE and its underlying mechanism in...
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Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors
Translocation-related sarcomas (TRSs) harbor an oncogenic fusion gene generated by chromosome translocation and account for approximately one-third...
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Molecular data reveal a structured puma (Puma concolor) population in northern Patagonia, Argentina
Understanding population structure and spatial distribution of genetic diversity is an important aspect of develo** appropriate management plans...
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Role of PumB antitoxin as a transcriptional regulator of the PumAB type-II toxin–antitoxin system and its endoribonuclease activity on the PumA (toxin) transcript
The PumAB type-II toxin–antitoxin (TA) system is encoded by pum AB genes that are organized into an operon. This system is encoded by the pUM505...
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Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis
Cellular stress can lead to several human disease pathologies due to aberrant cell death. The p53 family (tp53, tp63, and tp73) and downstream...
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BRD9 inhibition promotes PUMA-dependent apoptosis and augments the effect of imatinib in gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are primarily characterized by activating mutations of tyrosine kinase or platelet-derived growth factor...
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BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β
Alzheimer’s disease (AD) is characterized by accumulation of senile amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles causing progressive...
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WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal hematologic malignancy for which novel therapeutic targets and strategies are...
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First Camera Trap Evidence of Predation of a Black Capuchin Monkey, Sapajus nigritus, by a Cougar, Puma concolor, in the Brazilian Atlantic Forest
Predation of capuchin monkeys ( Sapajus spp. ) and other primates by cougars ( Puma concolor ) is reported by some studies, but empirical evidence is...
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Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis
Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and...
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Native, exotic, and livestock prey: assessment of puma Puma concolor diet in South American temperate region
Understanding the food habits of mammalian carnivores is crucial for the comprehension of the role of apex-predators in maintaining healthy...
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Scale-dependent seasonal habitat selection by jaguars (Panthera onca) and pumas (Puma concolor) in Panama
ContextFew habitat modeling studies consider multiple spatial or temporal scales; less identify the operative scale of an organism's response to...
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Differential Regulation of BBC3/PUMA and PMAIP1/Noxa in Ionizing Radiation: the Role of p53
AbstractThe p53 transcription factor is the most important sensor of ionizing radiation. Among the numerous effectors of p53 are the genes BBC3 and PMAIP1...
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Development of a 95 SNP panel to individually genotype mountain lions (Puma concolor) for microfluidic and other genoty** platforms
The mountain lion ( Puma concolor ) is one of the few remaining large predators in California, USA with density estimation from fecal genotypes...
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PumaPlex100: an expanded tool for puma SNP genoty** with low-yield DNA
The original PumaPlex is a high-throughput assay developed to genotype 25 single nucleotide polymorphisms (SNPs) in pumas ( Puma concolor ). Here, we...
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Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor
Accumulation of misfolded proteins in ER activates the unfolded protein response (UPR), a multifunctional signaling pathway that is important for...
