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PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis
Pleckstrin homeolike domain, family A, member 1 (PHLDA1) is a multifunctional protein that plays diverse roles in A variety of biological processes,...
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PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras
Activation of the Ras signaling pathway promotes the growth of malignant human glioblastoma multiforme (GBM). Mutations in Ras are rare in GBM,...
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BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer
Despite the frequent detection of KRAS driver mutations in patients with colorectal cancer (CRC), no effective treatments that target mutant KRAS...
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The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
BackgroundNeoadjuvant chemotherapy (NACT) becomes the first-line option for advanced tumors, while patients who are not sensitive to it may not...
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The long non-coding RNA SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression
Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is a relatively...
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Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow
Type 2 diabetes (T2D) has a complex etiology which is not yet fully elucidated. The identification of gene perturbations and hub genes of T2D may...
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Functional differentiation of the ovine preadipocytes —insights from gene expression profiling
The preadipocytes differentiation is a vital process of lipogenesis; exploring the molecular mechanisms of lipogenesis contributes to improve the...
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CPT-11 mitigates autoimmune diseases by suppressing effector T cells without affecting long-term anti-tumor immunity
The incidence of autoimmune diseases has significantly increased over the past 20 years. Excessive host immunoreactions and disordered...
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The potential role of hydrogen sulfide in cancer cell apoptosis
For a long time, hydrogen sulfide (H 2 S) has been considered a toxic compound, but recent studies have found that H 2 S is the third gaseous signaling...
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Serum miR-181а and miR-25 Levels in Patients with Breast Cancer or Benign Breast Disease
AbstractCirculating miR-181а and miR-25 , which reflect regulation of the expression of carcinogenesis-related genes, were assayed in patients with...
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Transcriptional response of murine microglia in Alzheimer’s disease and inflammation
BackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder and is the most common cause of late-onset dementia. Microglia, the primary innate...
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Identification of common stria vascularis cellular alteration in sensorineural hearing loss based on ScRNA-seq
BackgroundThe stria vascularis (SV), located in the lateral wall of the cochlea, maintains cochlear fluid homeostasis and mechanoelectrical...
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TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease
Chronic kidney disease (CKD) is characterized by the gradual loss of renal function and is a major public health concern. Risk factors for CKD...
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Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1
BackgroundPleckstrin homology-like domain family A member 1 (PHLDA1) is a tumor suppressor gene in gastric cancer, but its role regulated by circular...
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RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia
Preeclampsia (PE) is a pregnancy-associated disease, which is the major cause of mortality on maternity and perinatal infants. It is hypothesized...
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An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin
BackgroundT-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy...
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Exploring right ovary degeneration in duck and goose embryos by histology and transcriptome dynamics analysis
BackgroundThe development of asymmetric chick gonads involves separate developmental programs in the left and right gonads. In contrast to the left...
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Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes
Osteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identifying mechanisms and...
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High-throughput functional evaluation of human cancer-associated mutations using base editors
Comprehensive phenotypic characterization of the many mutations found in cancer tissues is one of the biggest challenges in cancer genomics. In this...
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A systematic summary of survival and death signalling during the life of hair follicle stem cells
Hair follicle stem cells (HFSCs) are among the most widely available resources and most frequently approved model systems used for studying adult...
