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Astrocytic NMDA Receptors
AbstractAstrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition....
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Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits
N -methyl- d -aspartate (NMDA) receptors are heterotetramers comprising two GluN1 and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length...
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Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
Blood–brain barrier (BBB) integrity is necessary to maintain homeostasis of the central nervous system (CNS). NMDA receptor (NMDAR) function and...
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Impaired Enzymatic Antioxidant Defense in Erythrocytes of Rats with Ammonia-Induced Encephalopathy: Role of NMDA Receptors
AbstractHepatic encephalopathy (HE), a neuropsychiatric disorder develo** in patients with severe hepatic dysfunction, has been known for more than...
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STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
Recent findings suggest an important role for the dysregulation of stromal interaction molecule (STIM) proteins, activators of store-operated Ca 2+ ...
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Protective effects of calcium ions via L-type calcium channels and NMDA receptors on prostaglandin E2-induced apoptosis in rat cortical cells
Calcium ions mediate a variety of physiological responses of develo** neurons including survival. The purpose of this study was to examine the...
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Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions
N -methyl-D-aspartate receptors (NMDARs) play vital roles in normal brain functions (i.e., learning, memory, and neuronal development) and various...
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Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants
N-methyl-D-aspartate receptors (NMDARs emerging from GRIN genes) are tetrameric receptors that form diverse channel compositions in neurons,...
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Glutamate and GABA Receptors of Nerveless Animals (Placozoa): Preadaptation to Neurotransmission
Abstract —The emergence of the nervous system is one of the most important events in the evolution of life on Earth. The details of this event remain...
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Impact of NMDA receptor activation on DNA damage in PC12 neuron-like cell cultures in the presence of β-amyloid peptides
ObjectiveThis study aimed to investigate the effect of low nanomolar concentrations of Aβ1–40 and Aβ25–35 on DNA double-strand breaks following NMDA...
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Calcium-permeable AMPA and kainate receptors of GABAergic neurons
This Commentary presents a brief discussion of the action of glutamate calcium permeable receptors present with neurons on the release of the...
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Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A
Dominant mutations in the human gene GRIN2A , encoding NMDA receptor (NMDAR) subunit GluN2A, make a significant and growing contribution to the...
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Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data
AbstractSome tricyclic antidepressants (TCAs), including amitriptyline (ATL), clomipramine (CLO), and desipramine (DES), are known to be effective...
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Structural insights into binding of therapeutic channel blockers in NMDA receptors
Excitatory signaling mediated by N -methyl- d -aspartate receptor (NMDAR) is critical for brain development and function, as well as for neurological...
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De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor
N-methyl- d -aspartate receptors (NMDARs) are members of the glutamate receptor family and participate in excitatory postsynaptic transmission...
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Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease
Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in Alzheimer’s disease (AD) pathogenesis and previous studies suggest that NMDA...
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Functional effects of disease-associated variants reveal that the S1–M1 linker of the NMDA receptor critically controls channel opening
The short pre-M1 helix within the S1–M1 linker (also referred to as the pre-M1 linker) between the agonist-binding domain (ABD, S1) and the M1...
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Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice
IRSp53 (or BAIAP2) is an abundant excitatory postsynaptic scaffolding/adaptor protein that is involved in actin regulation and has been implicated in...
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Structural Insights into Function of Ionotropic Glutamate Receptors
Abstract —Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission. They are implicated in nervous system development and...
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Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis
N-methyl-D-aspartate receptors (NMDAR) are glutamate-gated calcium channels named after their artificial agonist. NMDAR are implicated in cell...
