Search
Search Results
-
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic...
-
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
BackgroundMyotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular...
-
Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition
CD47 recognized by its macrophage receptor SIRPα serves as a “don’t eat-me” signal protecting viable cells from phagocytosis. How this is abrogated...
-
ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance
Accumulating evidence demonstrates that the activity regulation of ELK3, a member of the E26 transformation-specific oncogene family, is critical to...
-
Formation of Amyloid-Like Conformational States of β-Structured Membrane Proteins on the Example of OMPF Porin from the Yersinia pseudotuberculosis Outer Membrane
AbstractThe work presents results of the in vitro and in silico study of formation of amyloid-like structures under harsh denaturing conditions by...
-
TTYH family members form tetrameric complexes at the cell membrane
The conserved Tweety homolog (TTYH) family consists of three paralogs in vertebrates, displaying a ubiquitous expression pattern. Although considered...
-
Lipid and Lipidation in Membrane Fusion
Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion...
-
Biophysical Characterization of Membrane Proteins
Membrane proteins are responsible for a large variety of tasks in organisms and of particular interesting as drug targets. At the same time, they are...
-
XAF1 drives apoptotic switch of endoplasmic reticulum stress response through destabilization of GRP78 and CHIP
X-linked inhibitor of apoptosis-associated factor-1 (XAF1) is a stress-inducible tumor suppressor that is commonly inactivated in many human cancers....
-
Electrostatic switch mechanisms of membrane protein trafficking and regulation
Lipid-protein interactions are normally classified as either specific or general. Specific interactions refer to lipid binding to specific binding...
-
Fluoride Induces Neurocytotoxicity by Disrupting Lysosomal Iron Metabolism and Membrane Permeability
The detrimental effects of fluoride on neurotoxicity have been widely recorded, yet the detailed mechanisms underlying these effects remain unclear....
-
Lipidomic and Membrane Mechanical Signatures in Triple-Negative Breast Cancer: Scope for Membrane-Based Theranostics
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer associated with poor prognosis, higher grade, and a high rate of...
-
Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells
Cathepsin D (Cat D) is well known for its roles in metastasis, angiogenesis, proliferation, and carcinogenesis in cancer. Despite Cat D being a...
-
N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the...
-
Membrane Proteins as a Regulator for Antibiotic Persistence in Gram-Negative Bacteria
Antibiotic treatment failure threatens our ability to control bacterial infections that can cause chronic diseases. Persister bacteria are a...
-
Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure
VPS37A, an ESCRT-I complex component, is required for recruiting a subset of ESCRT proteins to the phagophore for autophagosome closure. However, the...
-
Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer
Hierarchical organization of integral membrane proteins (IMP) and lipids at the membrane is essential for regulating myriad downstream signaling. A...
-
Activation of kappa opioid receptor suppresses post-traumatic osteoarthritis via sequestering STAT3 on the plasma membrane
ObjectiveKappa opioid receptor (KOR) signaling is involved in joint development and inflammation in Osteoarthritis (OA), while the biochemical...
-
Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment
Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become...
-
Effects of monolauroyl-galactosylglycerol on membrane fatty acids and properties of Bacillus cereus
AbstractThe purpose of this study was to provide new ideas for the antibacterial mechanism of monolauroyl-galactosylglycerol (MLGG) from the...
