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Pressure sensing of lysosomes enables control of TFEB responses in macrophages
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable solutes. While the transport of diverse organic solutes across...
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Biogenesis of specialized lysosomes in differentiated keratinocytes relies on close apposition with the Golgi apparatus
Intracellular organelles support cellular physiology in diverse conditions. In the skin, epidermal keratinocytes undergo differentiation with gradual...
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Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However,...
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Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute...
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Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdown to coordinate programmes...
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MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
The lysosomal degradation of macromolecules produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways....
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Biochemically Reconstituted Fusion of Phagosomes with Endosomes and Lysosomes
Professional phagocytic cells, such as macrophages, ingest large particles into a specialized endocytic compartment, the phagosome, which eventually...
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Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells
BackgroundAmong the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid...
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Prefused lysosomes cluster on autophagosomes regulated by VAMP8
Lysosome–autophagosome fusion is critical to autophagosome maturation. Although several proteins that regulate this fusion process have been...
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Metabolomic profiling of single enlarged lysosomes
Lysosomes are critical for cellular metabolism and are heterogeneously involved in various cellular processes. The ability to measure lysosomal...
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Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as...
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Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite...
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Autophagy initiation triggers p150Glued–AP-2β interaction on the lysosomes and facilitates their transport
The endocytic adaptor protein 2 (AP-2) complex binds dynactin as part of its noncanonical function, which is necessary for dynein-driven...
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A novel sterol-binding protein reveals heterogeneous cholesterol distribution in neurite outgrowth and in late endosomes/lysosomes
We identified a mushroom-derived protein, maistero-2 that specifically binds 3-hydroxy sterol including cholesterol (Chol). Maistero-2 bound lipid...
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Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells
BackgroundRecent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells...
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