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Nanoparticles and Their Applications in Lipid Signaling
This chapter provides an overview of the diverse range of applications associated with nanoparticles. The application of nanoparticles in the medical...
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Lipid Signalling Methods and Protocols
This volume covers the latest advancements in the study of lipid signaling. The chapters in this book cover topics such as neuronal cells such as...
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Rafting on the Plasma Membrane: Lipid Rafts in Signaling and Disease
The plasma membrane is not a uniform phospholipid bilayer; it has specialized membrane nano- or microdomains called lipid rafts. Lipid rafts are...
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Measurement of Intracellular Ca2+ for Studying GPCR-Mediated Lipid Signaling
Intracellular Ca2+ can be conveniently monitored by sensitive Ca2+ fluorescent dyes in live cells. The Gαq involved lipid signaling pathways and,...
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The Interplay of Lipid Signaling in Musculoskeletal Cross Talk: Implications for Health and Disease
The intricate interplay between the muscle and bone tissues is a fundamental aspect of musculoskeletal physiology. Over the past decades, emerging...
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Using Micropatterned Supported Lipid Bilayers to Probe the Mechanosensitivity of Signaling Receptors
The ligand–receptor complexes in the cell–cell and cell–ECM interfaces mediate the mechanical coupling of cells to their microenvironment and...
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Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism
Fetal growth restriction (FGR) is a common complication of pregnancy and can have significant impact on obstetric and neonatal outcomes. Increasing...
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Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
BackgroundLipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood....
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ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway
BackgroundLigamentum flavum (LF) hypertrophy is the main cause of lumbar spinal canal stenosis (LSCS). Previous studies have shown that LF...
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ROS and Ca2+ signaling involved in important lipid changes of Chlorella pyrenoidosa under nitrogen stress conditions
Main conclusionNitrogen stress altered important lipid parameters and related genes in Chlorella pyrenoidosa via ROS and Ca 2+ signaling. The mutual...
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SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway
Pancreatic cancer (PC), a highly lethal malignancy, commonly exhibits metabolic reprogramming that results in therapeutic vulnerabilities....
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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development
BackgroundExtracellular vesicles (EVs) present in oviductal (OF) and uterine fluid (UF) have been shown to enhance bovine embryo quality during in...
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Effect of Leucine-enkephalin on Lipid Deposition and GSK-3β/mTOR Signaling in the Liver of Zebrafish
In the current study, we evaluated the effect of leucine-enkephalin (L-ENK) on lipid deposition and GSK-3β/mTOR signaling in zebrafish. Zebrafish...
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Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer
Colorectal cancer (CRC) is characterized by a complex tumor inflammatory microenvironment, while angiogenesis and immunosuppression frequently occur...
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GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway
In the process of inflammatory activation, macrophages exhibit lipid metabolism disorders and accumulate lipid droplets. Kupffer cells (KCs) are the...
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Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma
BackgroundAbnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an...
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Lipid Raft Facilitated Receptor Organization and Signaling: A Functional Rheostat in Embryonic Development, Stem Cell Biology and Cancer
Molecular views of plasma membrane organization and dynamics are gradually changing over the past fifty years. Dynamics of plasma membrane instigate...
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Lipid Binding of SH2 Domains
The Src homology 2 (SH2) domain is a modular protein interaction domain that specifically recognizes the phosphotyrosine (pY) motif of a target...
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Synthesis of Azo Analogs for Investigating Phosphatidic Acid-Mediated Signaling
Phosphatidic acid (PA) is a key signaling lipid that plays a crucial role in regulating various cellular processes. Studies have shown that...
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Analysis of Lipoprotein Signaling in Iris Melanocytes
Lipids are compounds involved in many biologic functions including cell structure, metabolism, energy storage and are involved in signaling. A...