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Identification of potential genetic causal variants for obesity-related traits using statistical fine map**
BackgroundObesity is highly influenced by heritability and variant effects. While previous genome-wide association studies (GWASs) have successfully...
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Analysis of tandem repeat units of the promoter of capsanthin/capsorubin synthase (Ccs) gene in pepper fruit
Capsanthin/capsorubin synthase ( Ccs ) gene is a key gene that regulates the synthesis of capsanthin and the development of red coloration in pepper...
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In silico analysis of the core signaling proteome from the barley powdery mildew pathogen (Blumeria graminis f.sp. hordei)
BackgroundCompared to other ascomycetes, the barley powdery mildew pathogen Blumeria graminis f.sp. hordei ( Bgh ) has a large genome (ca. 120 Mbp)...
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Expression of Reactive Oxygen Species in Junctional and Pocket Epithelium
The generation of reactive oxygen species (ROS) is part of an antimicrobial response to pathogenic challenge and potentially has a deleterious effect...
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Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation
ADP-ribosylation of proteins was first described in the early 1960's, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is...
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Macro domains as metabolite sensors on chromatin
How metabolism and epigenetics are molecularly linked and regulate each other is poorly understood. In this review, we will discuss the role of...
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Transcription factor RUNX1
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. RUNX1 controls hematopoiesis and angiogenesis and is indispensable...
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Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2
BackgroundChronic hemodynamic overloading leads to heart failure (HF) due to incompletely understood mechanisms. To gain deeper insight into the...
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Keratin 18 attenuates estrogen receptor α-mediated signaling by sequestering LRP16 in cytoplasm
BackgroundOncogenesis in breast cancer is often associated with excess estrogen receptor α(ERα) activation and overexpression of its coactivators....
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Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo
Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues; however the mechanisms underlying the...
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GCOD - GeneChip Oncology Database
BackgroundDNA microarrays have become a nearly ubiquitous tool for the study of human disease, and nowhere is this more true than in cancer. With...
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Regulation of intestinal epithelial cells transcriptome by enteric glial cells: impact on intestinal epithelial barrier functions
BackgroundEmerging evidences suggest that enteric glial cells (EGC), a major constituent of the enteric nervous system (ENS), are key regulators of...
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A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Poly-ADP-ribosylation is a post-translational modification catalyzed by PARP enzymes with roles in transcription and chromatin biology. Here we show...
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Proteomic analysis of mitochondria from the Bos taurus heart. II. Identification of mitochondrial soluble proteins
A fraction of the so-called mitochondrial soluble proteins was obtained after the destruction of purified mitochondria by sonication according to the...
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Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin
LRP16 was previously identified as an estrogen-induced gene in breast cancer cells. The responsiveness of LRP16 to estrogen and its functional...
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Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids
BackgroundChemotherapy (CT) resistance in ovarian cancer (OC) is broad and encompasses diverse unrelated drugs, suggesting more than one mechanism of...
