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SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins
SPACA6 is a sperm-expressed surface protein that is critical for gamete fusion during mammalian sexual reproduction. Despite this fundamental role,...
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teiresias, a Fruitless target gene encoding an immunoglobulin-superfamily transmembrane protein, is required for neuronal feminization in Drosophila
This study aims at identifying transcriptional targets of FruitlessBM (FruBM), which represents the major isoform of male-specific FruM transcription...
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Immunoglobulin heavy constant gamma gene evolution is modulated by both the divergent and birth-and-death evolutionary models
Immunoglobulin G (IgG) is one of the five antibody classes produced in mammals as part of the humoral responses accountable for protecting the...
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Genome-wide association studies for immunoglobulin concentrations in colostrum and serum in Chinese Holstein
BackgroundThe early death and health problems of calves caused substantial economic losses in the dairy industry. As the immune system of neonates...
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Angiopoietin-like protein 2 inhibits thrombus formation
Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet...
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Extracellular vesicle-cell adhesion molecules in tumours: biofunctions and clinical applications
Cell adhesion molecule (CAM) is an umbrella term for several families of molecules, including the cadherin family, integrin family, selectin family,...
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RETRACTED ARTICLE: ITGA3 acts as a purity-independent biomarker of both immunotherapy and chemotherapy resistance in pancreatic cancer: bioinformatics and experimental analysis
Contribution of integrin superfamily genes to treatment resistance remains uncertain. Genome patterns of thirty integrin superfamily genes were...
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VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancies to overcome clinically due to its insidious onset as...
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Integrative analysis of risk factors for immune-related adverse events of checkpoint blockade therapy in cancer
Immune-related adverse events (irAEs) induced by checkpoint inhibitors involve a multitude of different risk factors. Here, to interrogate the...
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Sialic Acid-Binding Ig-Like Lectins (Siglecs)
During the mid-1980s, in vitro rosette formation between macrophages and sheep erythrocytes was reported; however, sialidase treatment on...
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Staphylococcus aureus foldase PrsA contributes to the folding and secretion of protein A
BackgroundStaphylococcus aureus secretes a variety of proteins including virulence factors that cause diseases. PrsA, encoded by many Gram-positive...
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Impact of BSG/CD147 gene expression on diagnostic, prognostic and therapeutic strategies towards malignant cancers and possible susceptibility to SARS-CoV-2
BackgroundBSG (CD147) is a member of the immunoglobulin superfamily that shows roles for potential prognostics and therapeutics for metastatic...
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Fibrinogen-Related Proteins of Gastropoda Molluscs
AbstractFibrinogen-related proteins (FREPs) are calcium-dependent lectins with one fibrinogen domain and one or two immunoglobulin-like domains. The...
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Galectin-9, a pro-survival factor inducing immunosuppression, leukemic cell transformation and expansion
Leukemia is a malignancy of the bone marrow and blood originating from self-renewing cancerous immature blast cells or transformed leukocytes....
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TIGIT, a novel immune checkpoint therapy for melanoma
Melanoma is the most aggressive and deadliest type of skin cancer. In the last 10 years, immune checkpoint blockades (ICBs) including PD-1/PD-L1 and...
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Profiles of Natural and Designed Protein-Like Sequences Effectively Bridge Protein Sequence Gaps: Implications in Distant Homology Detection
Sequence-based approaches are fundamental to guide experimental investigations in obtaining structural and/or functional insights into...
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Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
Fc receptors (FcRs), specific to the Fc portion of immunoglobulin (Ig), are required to regulate immune responses against pathogenic infections....
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hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit
Our nervous system contains billions of neurons that form precise connections with each other through interactions between cell surface proteins. In Drosophila...
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Discovery of antitumor effects of leczymes
Sialic-acid binding lectin from bullfrog ( Rana catesbeiana ) eggs, cSBL, is a cytotoxic ribonuclease (RNase) belonging to the RNase A superfamily....
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Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat...
