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Fibrinogen-Related Proteins of Gastropoda Molluscs

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Abstract

Fibrinogen-related proteins (FREPs) are calcium-dependent lectins with one fibrinogen domain and one or two immunoglobulin-like domains. The FREPs of gastropod molluscs can undergo somatic diversification, which is unique among pathogen-recognizing molecules of invertebrates. The structure of the genomic regions encoding FREPs implies the possibility of alternative splicing and somatic mutagenesis. Since the discovery of FREPs in Biomphalaria glabrata, these molecules have been described in many gastropods. At least 14 subfamilies of FREPs are currently known. FREPs of different subfamilies selectively participate in the immune response to various pathogens. In particular, their role in defense reactions to trematode invasion and resistance to trematodes of particular species has been confirmed. The supposed functions of FREPs are diverse, ranging from the recognition of foreign matter to the opsonization and neutralization of pathogens. Despite the abundance of studies of FREPs, the Russian literature on this subject is scarce. The main purpose of this review is to analyze the available information on gastropod FREPs and to discuss their role among pattern recognition receptors of molluscs.

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The study was carried out with financial support from the Ministry Education of the Russian Federation (project No. VRFY-2023-0009).

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    E. E. Prokhorova & G. L. Ataev

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Prokhorova, E.E., Ataev, G.L. Fibrinogen-Related Proteins of Gastropoda Molluscs. Biol Bull Rev 13 (Suppl 2), S184–S198 (2023). https://doi.org/10.1134/S2079086423080091

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