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Cryopreservation of Iranian Markhoz goat fibroblast cells as an endangered national genetic resource
BackgroundThe continuous accessibility of local animals for sustainable use is being eroded annually. Thus, a strategic vision for the conservation...
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Establishment of Capra hircus somatic cells and induction of pluripotent stem-like cells
Capra hircus (goat) induced pluripotent stem cells (giPSCs) harbor enormous scientific value and contribute to cellular agriculture, animal cloning,...
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Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis
Clonal hematopoiesis (CH) is an independent risk factor for atherosclerotic cardiovascular disease. Murine models of CH suggest a central role of...
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Effects of 1,25(OH)2D3 on the Growth and Development of Skin Hair Follicles of Liaoning Cashmere Goat
AbstractThe Liaoning cashmere goat is a unique breed in China. It has an excellent germplasm resource with high villus yield, fine villus fibre...
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Reprogramming fibroblast into human iBlastoids
The study of early human embryogenesis has relied on the use of blastocysts donated to research or simple stem cell culture systems such as...
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Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds
Understanding the genomic features of livestock is essential for successful breeding programs and conservation. This information is scarce for local...
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Transcriptomic landscape reveals germline potential of porcine skin-derived multipotent dermal fibroblast progenitors
According to estimations, approximately about 15% of couples worldwide suffer from infertility, in which individuals with azoospermia or oocyte...
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A specific inflammatory suppression fibroblast subpopulation characterized by MHCII expression in human dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a significant cause of heart failure that requires heart transplantation. Fibroblasts play a central role in the...
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C-type natriuretic peptide promotes adipogenic differentiation of goat adipose–derived stem cells via cGMP/PKG/ p38 MAPK signal pathway
C-type natriuretic peptide (CNP) is a member of natriuretic peptide family, which plays unique roles in cardiovascular system. Once CNP binds to...
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Basic Fibroblast Growth Factor Induces Cholinergic Differentiation of Tonsil-Derived Mesenchymal Stem Cells
Background:Mesenchymal stem cells (MSCs) are considered a potential tool for regenerating damaged tissues due to their great multipotency into...
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The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition
BackgroundRenal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently...
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Single-cell RNA-seq reveals keratinocyte and fibroblast heterogeneity and their crosstalk via epithelial-mesenchymal transition in psoriasis
The pathogenesis of psoriasis, a chronic inflammatory autoimmune skin disease with a high global prevalence, remains unclear. We performed a...
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Murine skin-derived multipotent papillary dermal fibroblast progenitors show germline potential in vitro
BackgroundMany laboratories have described the in vitro isolation of multipotent cells with stem cell properties from the skin of various species...
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Establishment and characterization of immortalized human vocal fold fibroblast cell lines
PurposeVocal fold scarring is abnormal scar tissue in the lamina propria layer of the vocal fold. To facilitate investigation of vocal fold scarring,...
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Long-term preservation of established fibroblast lines from six‐banded armadillos (Euphractus sexcintus, Linnaeus, 1758) by extended passage and cryopreservation
Establishing new somatic cell cultures has raised significant attention as an effective and convenient way to preserve genetic samples for different...
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Genome-wide association study for cashmere traits in Inner Mongolia cashmere goat population reveals new candidate genes and haplotypes
BackgroundThe cashmere goat industry is one of the main pillars of animal husbandry in Inner Mongolia Autonomous Region, and plays an irreplaceable...
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Reproductive Biotechnologies Applied to the Female Sheep and Goat
Applying reproductive biotechnologies to female sheep and goats allows to improving animal protein production, advancing scientific knowledge with...
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The β-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential
Recruitment of fibroblasts to tumors and their activation into cancer-associated fibroblasts (CAFs) is a strategy used by tumor cells to direct...
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Screening Indels from the whole genome to identify the candidates and their association with economic traits in several goat breeds
In the present study, the re-sequencing of our previous whole-genome sequencing (WGS) for selected individuals of Dazu-black goat (DBG) and...
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The cytotoxic effects of bisphenol A alternatives in human lung fibroblast MRC5 cells
BackgroundEndocrine-disrupting compounds (EDCs) disrupt homeostasis via the dysregulation of hormone synthesis and metabolism. Bisphenol A (BPA) is...
