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Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model
Down syndrome (DS) is the most common chromosomal abnormality in live-born infants and is caused by trisomy of chromosome 21. Most individuals with...
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Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical region of human chromosome...
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Shrimp Immune System and Immune Responses
Shrimp, being an invertebrate, lack a vertebrate-like adaptive immune system. However, an efficient innate immune system, consisting of physical...
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Differential microRNA expression profile in blood of children with Down syndrome suggests a role in immunological dysfunction
Down syndrome (DS), caused by trisomy of chromosome 21 (HSA21), results in a broad range of phenotypes. However, the determinants contributing to the...
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The clinical significance of circulating DSCAM-AS1 in patients with ER-positive breast cancer and construction of its competitive endogenous RNA network
AbstractLong Non-Coding RNAs (lncRNAs), with diagnostic and therapeutic applications in malignancies, are newly described tumour-related molecules....
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Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome
BackgroundHematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias,...
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The physiology of alternative splicing
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss...
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Tailored midgut gene expression in Spodoptera litura (Lepidoptera: Noctuidae) feeding on Zea mays indicates a tug of war
Spodoptera litura is a destructive lepidopteran generalist pest widespread in tropical and subtropical regions and causes huge yield loss by...
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Insect Defense Proteins and Peptides
The composition of insect hemolymphHemolymph can change depending on many factors, e.g. access to nutrients, stress conditions, and current needs of...
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Drosophila olfaction as a model system for studying human neurological disorders
The fruit fly, Drosophila melanogaster , has been one of the finest systems for decoding myriad puzzles across different domains of biology. Beyond...
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In-depth transcriptomic analysis of Anopheles gambiae hemocytes uncovers novel genes and the oenocytoid developmental lineage
BackgroundHemocytes are immune cells that patrol the mosquito hemocoel and mediate critical cellular defense responses against pathogens. However,...
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Prospects of Vaccination in Crustaceans with Special Reference to Shrimp
Among different categories of management options available to combat infectious diseases in shrimp, vaccination is one of the most promising ones....
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Host-pathogen coevolution drives innate immune response to Aphanomyces astaci infection in freshwater crayfish: transcriptomic evidence
BackgroundFor over a century, scientists have studied host-pathogen interactions between the crayfish plague disease agent Aphanomyces astaci and...
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Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model
Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions...
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Revisiting Dscam diversity: lessons from clustered protocadherins
The complexity of neuronal wiring relies on the extraordinary recognition diversity of cell surface molecules. Drosophila Dscam1 and vertebrate...
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Zelluläre Membranen. Die Zellmembran: Umschlagplatz für Stoffe und Information
In der ZellmembranZellmembran, wie in intrazellulären MembranenMembran auch, liegt nach Erkenntnissen vom Beginn des 20. Jahrhunderts als...
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Countering beta-cypermethrin: partitioning roles of the insect gut and its bacteria
Insects and their gut bacteria can degrade insecticides separately, which is helpful for insecticide resistance development. However, there is little...
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Unraveling the etiology of shrimp diseases: a review through the perspectives of gut microbial dynamics
Aquaculture plays a vital role in meeting global food demand, and shrimp farming is a major contributor to this industry. Despite the immense...
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Analysis of Splicing Regulation by Third-Generation Sequencing
In Metazoa, the diversity of transcripts produced by the RNA Polymerase II is generated essentially through post-transcriptional processing of the...