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Diclofenac sodium effectively inhibits the biofilm formation of Staphylococcus epidermidis
Staphylococcus epidermidis is an opportunistic pathogen commonly implicated in medical device-related infections. Its propensity to form biofilms not...
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Proteome profiling, biochemical and histological analysis of diclofenac-induced liver toxicity in Yersinia enterocolitica and Lactobacillus fermentum fed rat model: a comparative analysis
Diclofenac is a hepatotoxic non-steroidal anti-inflammatory drug (NSAID) that affects liver histology and its protein expression levels. Here, we...
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The nephroprotective effect of ellagic acid against diclofenac-induced renal injury in male rats: role of Nrf2/HO-1 and NF-κB/TNF-α pathways
Despite the promising effect of the nonsteroidal anti-inflammatory drug (NSAIDs) on controlling the chronic symptoms of different diseases, their...
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Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with Mexidol on Blood Pressure and Hematological Indices in Rats
Abstract—The effect on blood pressure (BP), hematological indices, and body weight of rats was evaluated for nonselective cyclooxygenase (COX)...
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Diclofenac-loaded PLGA nanoparticles downregulate LasI/R quorum sensing genes in pathogenic P. aeruginosa isolates
Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible polymer that can gradually and consistently release drugs in a controlled manner. In this...
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Protective effect of curcumin on the kidney of diclofenac sodium-challenged mice: apoptotic, redox potential and histopathological outcomes
BackgroundThe renal burden imposed by diclofenac sodium (DS) remedy is a significant concern and limits the extension in its clinical application....
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Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats
BackgroundDiclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally prescribed for the treatment of pain. In spite of the...
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Influence of hydroethanolic extract of Cassia spectabilis leaves on diclofenac-induced oxidative stress and hepatorenal damage in Wistar rats
BackgroundThe medicinal potential of plant extracts for the management of liver and kidney disorders in humans has been harnessed for the past...
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Influence of chemical and mineralogical soil properties on the adsorption of sulfamethoxazole and diclofenac in Mediterranean soils
BackgroundThe irrigation with treated wastewaters can be a way for the introduction of organic contaminants in soils. However, their adsorption onto...
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Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with Mexidol on Behavior in Rats
AbstractThe effect of nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitor etoricoxib and nonselective COX...
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Ability of Mexidol to Enhance Antiexudative Effect of Diclofenac Sodium and Etoricoxib in Rats and Mice with Carrageenan-Induced Edema
AbstractNonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most widely used drugs in existence. However, they can cause numerous side...
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Removal of diclofenac by a local bacterial consortium: UHPLC-ESI-MS/MS analysis of metabolites and ecotoxicity assessment
Diclofenac (DCF) belongs to the class of nonsteroidal anti-inflammatory drugs, which is one of the most consumed by population and detected in raw...
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New Diclofenac Derivatives as Anti-Microbial, Anti-Inflammatory Agents: Design, Synthesis, Biological Screening, and Molecular Docking Study
AbstractDiclofenac is considered one of the best drugs used as anti-inflammatory agent, so in the present work new diclofenac derivatives containing...
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Diclofenac mitigates virulence of multidrug-resistant Staphylococcus aureus
Staphylococcus aureus is an opportunistic pathogen that has the ability to cause a wide range of diseases including superficial infection and severe...
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Effect of probiotic supplementation on oxidative stress markers in rats with diclofenac-induced hepatotoxicity
In this study, we have investigated the effect of an antioxidant probiotic pretreatment toward an overdose of diclofenac in rats (100 mg/kg bw). Rats...
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Assessing the bioremediation potential of indigenously isolated Klebsiella sp. WAH1 for diclofenac sodium: optimization, toxicity and metabolic pathway studies
Among the various pharmaceutical pollutants, diclofenac sodium (DFS), a widely prescribed non-steroid anti-inflammatory drug is detected in the...
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Effect of the anti-inflammatory drug diclofenac on lipid composition of bacterial strain Raoultella sp. KDF8
The strain Raoultella sp. KDF8 was cultivated on three sources of carbon and energy, glycerol, ethanol and diclofenac, for periods of time ranging...
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RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model
BackgroundDespite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood....
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Exploration of NMI-MsCl mediated amide bond formation for the synthesis of novel 3,5-substituted-1,2,4-oxadiazole derivatives: synthesis, evaluation of anti-inflammatory activity and molecular docking studies
We herein report the facile synthesis of a series of 3,5-substituted-1,2,4-oxadiazole derivatives 9a–e and 10a–e in good to excellent yields by...
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Projected future of slender-billed vulture: Habitat distribution modelling and population study in Northern India
Slender-billed vulture is an Old-world vulture classified as critically endangered, yet insufficiently studied on account of future habitat and...
