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DiCleave: a deep learning model for predicting human Dicer cleavage sites
BackgroundMicroRNAs (miRNAs) are a class of non-coding RNAs that play a pivotal role as gene expression regulators. These miRNAs are typically...
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Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3′-end modifications
The human let-7 miRNA family consists of thirteen members that play critical roles in many biological processes, including development timing and...
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ReCGBM: a gradient boosting-based method for predicting human dicer cleavage sites
BackgroundHuman dicer is an enzyme that cleaves pre-miRNAs into miRNAs. Several models have been developed to predict human dicer cleavage sites,...
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DICER: structure, function, and regulation
Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
Guanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important...
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The conserved single-cleavage mechanism of animal DROSHA enzymes
RNase III enzymes typically cleave both strands of double-stranded RNAs (dsRNAs). We recently discovered that a human RNase III, DROSHA, exhibits a...
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Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
RNase2 is the member of the RNaseA family most abundant in macrophages. Here, we knocked out RNase2 in THP-1 cells and analysed the response to...
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Regulation of MicroRNAs
MicroRNAs are RNAs of about 18–24 nucleotides in lengths, which are found in the small noncoding RNA class and have a crucial role in the...
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Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours
Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s)...
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Identification and characterization of Dicer-like genes in leaf rust pathogen (Puccinia triticina) of wheat
Puccinia triticina ( P. triticina ) is one of the most devastating fungal pathogens of wheat which causes significant annual yield loss to the crop....
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Unveiling the world of bee microRNAs: computational identification and characterization of pathway genes, conserved microRNAs, and their targets
MicroRNAs (miRNAs) are noncoding RNA sequences crucial for post-transcriptional gene expression control and regulation. This study employs a...
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tRF-3013b inhibits gallbladder cancer proliferation by targeting TPRG1L
BackgroundtRNA-derived fragments (tRFs) are newly discovered noncoding RNAs and regulate tumor progression via diverse molecular mechanisms. However,...
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The RNA–RNA base pairing potential of human Dicer and Ago2 proteins
The ribonuclease Dicer produces microRNAs (miRNAs) and small interfering RNAs that are handed over to Ago proteins to control gene expression by...
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Identification and expression analysis of 21-nt and 24-nt phased small interfering RNAs in maize tissues
Phased secondary small interfering RNAs (phasiRNAs) are generated by double-stranded RNA (dsRNAs), which are cleaved by Dicer as a phase set....
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Widespread occurrence of microRNA-mediated target cleavage on membrane-bound polysomes
BackgroundSmall RNAs (sRNAs) including microRNAs (miRNAs) and small interfering RNAs (siRNAs) serve as core players in gene silencing at...
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RNA Interference (RNAi ) as a Tool for High-Resolution Phenotypic Screening of the Pathogenic Yeast Candida glabrata
After its discovery RNA interference (RNAi) has become a powerful tool to study gene functions in different organisms. RNAi has been applied at...
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Genome-wide identification of Sclerotinia sclerotiorum small RNAs and their endogenous targets
BackgroundSeveral phytopathogens produce small non-coding RNAs of approximately 18–30 nucleotides (nt) which post-transcriptionally regulate gene...
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44 Current Challenges in miRNomics
Mature microRNAs (miRNAs) are short RNA sequences about 18–24 nucleotide long, which provide the recognition key within RISC for the...
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MicroRNA-9119 regulates cell viability of granulosa cells in polycystic ovarian syndrome via mediating Dicer expression
Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. Although much is understood concerning the pathology...
