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Chromatin regulator SMARCAL1 modulates cellular lipid metabolism
Biallelic mutations of the chromatin regulator SMARCAL1 cause Schimke Immunoosseous Dysplasia (SIOD), characterized by severe growth defects and...
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Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression...
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Protein–Metabolite Interactions Shape Cellular Metabolism and Physiology
Protein–metabolite interactions regulate many important cellular processes but still remain understudied. Recent technological advancements are...
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Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance
Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria, potentially acting as antagonists by inducing cell...
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Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Human mitochondrial NAD(P) + -dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy....
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Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism
BackgroundEnergy homeostasis is essential for the adaptation of animals to their environment and some wild animals keep low metabolism adaptive to...
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Telomeres and Mitochondrial Metabolism: Implications for Cellular Senescence and Age-related Diseases
Cellular senescence is an irreversible cell arrest process, which is determined by a variety of complicated mechanisms, including telomere attrition,...
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Assaying Mitochondrial Respiration as an Indicator of Cellular Metabolism and Fitness
Mitochondrial respiration is an essential component of cellular metabolism. It is a process of energy conversion through enzymatically mediated...
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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism
Memory T cells demonstrate superior in vivo persistence and antitumor efficacy. However, methods for manufacturing less differentiated T cells are...
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Regulation of PPARγ/CPT-1 expression ameliorates cochlear hair cell injury by regulating cellular lipid metabolism and oxidative stress
This study aimed to investigate the protective effects of PPARγ/CPT-1 regulation on cisplatin-induced cochlear hair cell injury. The viability,...
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Cellular Senescence
Cellular senescence was first defined as replicative senescence after the works of Hayflick. Later this concept was extended to many other pathways...
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Fermentative Metabolism
Metabolic pathways are mosaics of a limited set of metabolic modules and prototypic reactions. Mosaic pathways also include important metabolic...
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Investigations of cellular copper metabolism in ovarian cancer cells using a ratiometric fluorescent copper dye
AbstractImbalances in metal homeostasis have been implicated in the progression and drug response of cancer cells. Understanding these changes will...
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Mitochondria, metabolism, and aging in yeast
Quantitative and qualitative changes in metabolism take place when the lifespan is extended in yeast either by genetic or nutritional manipulation....
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Reciprocal regulation of cellular mechanics and metabolism
Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the cytoskeleton or distortion of the cell and organelles,...
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The modular biochemical reaction network structure of cellular translation
Translation is an essential attribute of all living cells. At the heart of cellular operation, it is a chemical information decoding process that...
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Multiple roles played by the mitochondrial citrate carrier in cellular metabolism and physiology
The citrate carrier (CIC) is an integral protein of the inner mitochondrial membrane which catalyzes the efflux of mitochondrial citrate (or other...
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Regulation of cellular and systemic sphingolipid homeostasis
One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual “Sphinx-like” lipids from the brain. Today, we know that...
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Reactive Nitrogen Species in Plant Metabolism
Reactive nitrogen species are a set of highly reactive molecules that derive from nitric oxide and oxidative metabolism, such as nitrogen dioxide,...