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Breakthrough of solid tumor treatment: CAR-NK immunotherapy
As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety...
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In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy
Natural killer (NK) cells have clinical potential against cancer; however, multiple limitations hinder the success of NK cell therapy. Here, we...
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High yield killing of lymphoma cells by anti-CD22 CAR-NK cell therapy
Chimeric antigen receptors (CARs) offer a promising new approach for targeting B cell malignancies through the immune system. Despite the proven...
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Emerging roles of CAR-NK cell therapies in tumor immunotherapy: current status and future directions
Cancer immunotherapy harnesses the body’s immune system to combat malignancies, building upon an understanding of tumor immunosurveillance and immune...
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Intrathecal CAR-NK cells infusion for isolated CNS relapse after allogeneic stem cell transplantation: case report
A 24-year-old man with central nervous system (CNS) involvement of T-cell lineage acute lymphoblastic leukemia received sibling allogeneic stem cell...
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Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells
BackgroundRedirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in develo** off-the-shelf CAR therapeutics...
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Chimeric Antigen Receptor-Engineered Natural Killer (CAR NK) Cells in Cancer Treatment; Recent Advances and Future Prospects
Natural Killer (NK) cells are critical members of the innate immunity lymphocytes and have a critical role in host defense against malignant cells....
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CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies
Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The...
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Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy
In recent decades, a new method of cellular immunotherapy was introduced based on engineering and empowering the immune effector cells. In this type...
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Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have...
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Chimeric antigen receptor-natural killer cells: a promising sword against insidious tumor cells
Natural killer (NK) cells are a critical component of innate immunity, particularly in initial cancer recognition and inhibition of additional tumor...
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Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
BackgroundNatural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral...
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GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint
BackgroundNK cell is one of innate immune cells and can protect the body from cancer-initiating cells. It has been reported that GPR116 receptor is...
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Synapse-tuned CARs enhance immune cell anti-tumor activity
Chimeric antigen receptor (CAR) technologies have been clinically implemented for the treatment of hematological malignancies; however, solid tumors...
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Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method
Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be...
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Challenges of chimeric antigen receptor-T/natural killer cell therapy in the treatment of solid tumors: focus on colorectal cancer and evaluation of combination therapies
Colorectal cancer (CRC) is the second most common cancer globally and one of the deadliest human malignancies. Traditional therapies, such as...
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Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies
Advancements in adoptive cell therapy over the last four decades have revealed various new therapeutic strategies, such as chimeric antigen receptors...
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The role of the natural killer (NK) cell modulation in breast cancer incidence and progress
The importance of the immune system on tumor surveillance has been investigated for many years, and its impact on controlling tumor progression has...
